Detailed information of TA system TA206493

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 284282..285918
• Replicon: chromosome
• Accession: NZ_CP076817
• Organism: Acinetobacter baumannii strain UC24137

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A7U4NHR9
• Locus tag: KQ257_RS01355
• Protein ID: WP_000737055.1
• Coordinates: 284587..285918 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KQ257_RS01350
• Protein ID: WP_001101310.1
• Coordinates: 284282..284590 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ257_RS01345 (KQ257_01340)	283014..283562	-	549	WP_004747161.1	TetR/AcrR family transcriptional regulator	-
KQ257_RS01350 (KQ257_01345)	284282..284590	-	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
KQ257_RS01355 (KQ257_01350)	284587..285918	-	1332	WP_000737055.1	HipA domain-containing protein	Toxin
KQ257_RS01360 (KQ257_01355)	286211..286651	+	441	WP_004747159.1	HD domain-containing protein	-
KQ257_RS01365 (KQ257_01360)	286686..287330	-	645	WP_000817313.1	hypothetical protein	-
KQ257_RS01370 (KQ257_01365)	287342..288313	-	972	WP_109433629.1	5'/3'-nucleotidase SurE	-
KQ257_RS01375 (KQ257_01370)	288441..289604	-	1164	WP_004747155.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51203.28 Da
• Isoelectric Point: 4.8549

>T206493 WP_000737055.1 NZ_CP076817:c285918-284587 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T206493 NZ_CP102458:151156-151557 [Burkholderia multivorans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTGGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAGCTCGAGTACGGCGTGACGGTATGCGCCAATC
CGGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTGGCGCCGTTCGACGGAGCGGCTGCGCAGGCA
TACGGCCCCATTCGCGAGGCGACGCGGGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCGGTATCGCT
CGACGTCGTGCTGGTGACCAACCACGAGCGTGATTTCGCGAGTTATCCGGGCTTGCGGCTCGAGAACTGGCTGATCGGCT
AG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT206493 WP_001101310.1 NZ_CP076817:c284590-284282 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT206493 NZ_CP102458:150920-151156 [Burkholderia multivorans]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTGGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGATGAAATTCGCATCCGGCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCCGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGGTTGGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4NHR9