Detailed information of TA system TA206489

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1503604..1504283
• Replicon: chromosome
• Accession: NZ_CP076814
• Organism: Acinetobacter baumannii strain UC21460

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: KQ256_RS07240
• Protein ID: WP_000838146.1
• Coordinates: 1503604..1503786 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: KQ256_RS07245
• Protein ID: WP_000966688.1
• Coordinates: 1503879..1504283 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ256_RS07200 (KQ256_07250)	1498939..1499343	+	405	WP_000247952.1	hypothetical protein	-
KQ256_RS07205 (KQ256_07255)	1499315..1499683	+	369	WP_001993865.1	hypothetical protein	-
KQ256_RS07210 (KQ256_07260)	1499685..1500083	+	399	WP_002062850.1	phage tail terminator-like protein	-
KQ256_RS07215 (KQ256_07265)	1500085..1500303	+	219	WP_002002228.1	hypothetical protein	-
KQ256_RS07220 (KQ256_07270)	1500399..1500752	+	354	WP_032051762.1	hypothetical protein	-
KQ256_RS07225 (KQ256_07275)	1500752..1501723	+	972	WP_046693290.1	hypothetical protein	-
KQ256_RS07230 (KQ256_07280)	1501776..1502693	+	918	WP_000094273.1	phage tail tube protein	-
KQ256_RS07235 (KQ256_07285)	1502763..1503278	+	516	WP_001185592.1	hypothetical protein	-
KQ256_RS07240 (KQ256_07290)	1503604..1503786	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
KQ256_RS07245 (KQ256_07295)	1503879..1504283	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KQ256_RS07250 (KQ256_07300)	1504383..1504559	+	177	WP_075149899.1	hypothetical protein	-
KQ256_RS07255 (KQ256_07305)	1504568..1504891	+	324	WP_000523929.1	DUF4236 domain-containing protein	-
KQ256_RS07260 (KQ256_07310)	1504923..1505606	+	684	WP_000720504.1	hypothetical protein	-
KQ256_RS07265 (KQ256_07315)	1505678..1506004	+	327	WP_000721696.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1467322..1524806	57484

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T206489 WP_000838146.1 NZ_CP076814:1503604-1503786 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T206489 NZ_CP102441:1953086-1953841 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGCTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT206489 WP_000966688.1 NZ_CP076814:1503879-1504283 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT206489 NZ_CP102441:1952583-1952951 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6