Detailed information of TA system TA206488

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 373644..374297
• Replicon: chromosome
• Accession: NZ_CP076814
• Organism: Acinetobacter baumannii strain UC21460

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KQ256_RS01855
• Protein ID: WP_046693176.1
• Coordinates: 373908..374297 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: KQ256_RS01850
• Protein ID: WP_001288210.1
• Coordinates: 373644..373901 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ256_RS01830 (KQ256_01830)	369162..370169	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
KQ256_RS01835 (KQ256_01835)	370188..370565	+	378	WP_001216380.1	50S ribosomal protein L17	-
KQ256_RS01840 (KQ256_01840)	370747..372237	+	1491	WP_046693177.1	NAD(P)/FAD-dependent oxidoreductase	-
KQ256_RS01845 (KQ256_01845)	372284..373456	-	1173	WP_001190547.1	acyl-CoA dehydrogenase family protein	-
KQ256_RS01850 (KQ256_01850)	373644..373901	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
KQ256_RS01855 (KQ256_01855)	373908..374297	+	390	WP_046693176.1	membrane protein	Toxin
KQ256_RS01860 (KQ256_01860)	375067..376152	+	1086	WP_000049106.1	hypothetical protein	-
KQ256_RS01865 (KQ256_01865)	376230..376796	+	567	WP_000651536.1	rhombosortase	-
KQ256_RS01870 (KQ256_01870)	376984..379179	+	2196	WP_001158911.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15691.00 Da
• Isoelectric Point: 10.4945

>T206488 WP_046693176.1 NZ_CP076814:373908-374297 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLAEWRKLKTLEKLY

Nucleotide

• Length: 390 bp

>T206488 NZ_CP102441:1876259-1876669 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGACACCAACATCTGCATCTTCACCATCAAAAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCACCC
CAATCGTGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT206488 WP_001288210.1 NZ_CP076814:373644-373901 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT206488 NZ_CP102441:1876017-1876259 [Pseudomonas aeruginosa]
ATGAGGTGTGTCGTGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCCGTCGCGCT
TCCTGATGACGTTAAGCGTGTGGATGTGGTCGCTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGCGAGTCTTGGGATA
GCTGGTTCGATGGCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTC
TGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7