Detailed information of TA system TA206486

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2732868..2733521
• Replicon: chromosome
• Accession: NZ_CP076812
• Organism: Acinetobacter baumannii strain UC23022

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A427QZH0
• Locus tag: KQ253_RS13265
• Protein ID: WP_000931891.1
• Coordinates: 2732868..2733257 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: KQ253_RS13270
• Protein ID: WP_253526300.1
• Coordinates: 2733264..2733521 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ253_RS13250 (KQ253_13170)	2727986..2730181	-	2196	WP_001158905.1	TRAP transporter large permease subunit	-
KQ253_RS13255 (KQ253_13175)	2730369..2730935	-	567	WP_000651536.1	rhombosortase	-
KQ253_RS13260 (KQ253_13180)	2731013..2732098	-	1086	WP_000049104.1	hypothetical protein	-
KQ253_RS13265 (KQ253_13185)	2732868..2733257	-	390	WP_000931891.1	hypothetical protein	Toxin
KQ253_RS13270 (KQ253_13190)	2733264..2733521	-	258	WP_253526300.1	succinate dehydrogenase assembly factor 2	Antitoxin
KQ253_RS13275 (KQ253_13195)	2733709..2734881	+	1173	WP_001190558.1	acyl-CoA dehydrogenase family protein	-
KQ253_RS13280 (KQ253_13200)	2734931..2736421	-	1491	WP_253526301.1	NAD(P)/FAD-dependent oxidoreductase	-
KQ253_RS13285 (KQ253_13205)	2736603..2736980	-	378	WP_001216380.1	50S ribosomal protein L17	-
KQ253_RS13290 (KQ253_13210)	2736999..2738006	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15635.91 Da
• Isoelectric Point: 10.3890

>T206486 WP_000931891.1 NZ_CP076812:c2733257-2732868 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T206486 NZ_CP102441:1017397-1017696 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10334.81 Da
• Isoelectric Point: 4.6150

>AT206486 WP_253526300.1 NZ_CP076812:c2733521-2733264 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDLYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT206486 NZ_CP102441:1017693-1017983 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Structures

Toxin

• AlphaFold DB: A0A427QZH0