206485

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 10323..10911 Replicon plasmid p2UC20804
Accession NZ_CP076809
Organism Acinetobacter baumannii strain UC20804

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag KQ254_RS19605 Protein ID WP_000438826.1
Coordinates 10323..10610 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag KQ254_RS19610 Protein ID WP_001983304.1
Coordinates 10597..10911 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ254_RS19575 (KQ254_19475) 5583..6188 - 606 WP_000447788.1 LysE family translocator -
KQ254_RS19580 (KQ254_19480) 6238..7065 - 828 WP_000073658.1 AraC family transcriptional regulator -
KQ254_RS19585 (KQ254_19485) 7239..7945 - 707 Protein_11 IS1 family transposase -
KQ254_RS19590 (KQ254_19490) 8036..8878 - 843 WP_002002480.1 carbapenem-hydrolyzing class D beta-lactamase OXA-58 -
KQ254_RS19595 (KQ254_19495) 9083..9787 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
KQ254_RS19600 (KQ254_19500) 9821..9982 - 162 WP_153603871.1 hypothetical protein -
KQ254_RS19605 (KQ254_19505) 10323..10610 + 288 WP_000438826.1 BrnT family toxin Toxin
KQ254_RS19610 (KQ254_19510) 10597..10911 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
KQ254_RS19615 (KQ254_19515) 11039..13450 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
KQ254_RS19620 (KQ254_19520) 13755..14216 + 462 WP_000761346.1 DIP1984 family protein -
KQ254_RS19625 (KQ254_19525) 14533..14964 - 432 WP_000390052.1 hypothetical protein -
KQ254_RS19630 (KQ254_19530) 14982..15248 - 267 WP_006581723.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 - 1..17469 17469


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T206485 WP_000438826.1 NZ_CP076809:10323-10610 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T206485 NZ_CP102441:799565-799843 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTTGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT206485 WP_001983304.1 NZ_CP076809:10597-10911 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT206485 NZ_CP102441:799855-800160 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References