Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 1053281..1053934 Replicon chromosome
Accession NZ_CP076807
Organism Acinetobacter baumannii strain UC20804

Toxin (Protein)


Gene name cptA Uniprot ID A0A2S4T466
Locus tag KQ254_RS05090 Protein ID WP_000607071.1
Coordinates 1053545..1053934 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KQ254_RS05085 Protein ID WP_001288210.1
Coordinates 1053281..1053538 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ254_RS05065 (KQ254_05045) 1048797..1049804 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
KQ254_RS05070 (KQ254_05050) 1049823..1050200 + 378 WP_001216380.1 50S ribosomal protein L17 -
KQ254_RS05075 (KQ254_05055) 1050382..1051872 + 1491 WP_049081867.1 NAD(P)/FAD-dependent oxidoreductase -
KQ254_RS05080 (KQ254_05060) 1051921..1053093 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
KQ254_RS05085 (KQ254_05065) 1053281..1053538 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
KQ254_RS05090 (KQ254_05070) 1053545..1053934 + 390 WP_000607071.1 membrane protein Toxin
KQ254_RS05095 (KQ254_05075) 1054704..1055789 + 1086 WP_000049106.1 hypothetical protein -
KQ254_RS05100 (KQ254_05080) 1055867..1056433 + 567 WP_000651536.1 rhombosortase -
KQ254_RS05105 (KQ254_05085) 1056621..1058816 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T206483 WP_000607071.1 NZ_CP076807:1053545-1053934 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T206483 NZ_CP102440:15431-15742 [Klebsiella pneumoniae]
GTGCATGTTATATCACGAGCCCCTTTTGATGAGGCGGCGAGACACTATCCGAATGATGCTGTGGCCATCGATGACACCTA
TCGTGTACTAAAGCGGGTTGTCGCAAAAAAACCGGATGAGCTAAAGCGATACTTTACTAGTCTGGATCGCATGAAATACC
GGGAAAAATGGTGGGTTATCGATATCGGCGGTAATAACCTTAGAATGATGTTTTTTGCTGATTTTGAGCGCGGAAAGATA
TTCGTCAAACACATAACCACCCATGCTGAATATGATCGCTTAACGAAATATTATCGGGAGCACAAAGAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT206483 WP_001288210.1 NZ_CP076807:1053281-1053538 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT206483 NZ_CP102440:15739-16155 [Klebsiella pneumoniae]
ATGATTTTTAGCGATGCCATTAAAGCGGCGAATGACCTGGCGAGTATTGTCCCTCTGCTGGGTGGTAGCTCGTCCCGCAA
AGATTACGAAGAGGCGCTTAAACTCGTTGAATATCTTCTGGAACATGACCCGGACAGCCCGCTGGTTGATATGCTGACTG
CCCGCATCGATGCCTGGGAAGATAACGCGGTGGAATTTGAAGAATTTAATACGCGCATCGAAGCAGGCAAAAACGGTGTA
TCGTTGCTGCGGGTTCTTATGCAGCAACACGGGCTTTCACAGTCCGATTTTGAAAACGAGATAGGCAAAAAATCGCTCGT
CAGCCGGATCCTCAGTGGTGAACGCAGTCTGACCCTTGATCACATGCGGGCGCTGGCAAATCGATTTCAAATCCCGGTCT
CGATGTTTGTTGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4T466

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References