206482

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2953..3541 Replicon plasmid p2UC24371
Accession NZ_CP076806
Organism Acinetobacter baumannii strain UC24371

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag KQ251_RS19780 Protein ID WP_000438826.1
Coordinates 2953..3240 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag KQ251_RS19785 Protein ID WP_001983304.1
Coordinates 3227..3541 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ251_RS19765 (KQ251_19690) 1..930 + 930 WP_005133531.1 replication initiation protein RepM -
KQ251_RS19770 (KQ251_19695) 1009..1533 + 525 WP_005127114.1 plasmid replication DNA-binding protein -
KQ251_RS19775 (KQ251_19700) 1700..2629 - 930 WP_045900839.1 potassium channel family protein -
KQ251_RS19780 (KQ251_19705) 2953..3240 + 288 WP_000438826.1 BrnT family toxin Toxin
KQ251_RS19785 (KQ251_19710) 3227..3541 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
KQ251_RS19790 (KQ251_19715) 3669..6080 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
KQ251_RS19795 (KQ251_19720) 6385..6846 + 462 WP_000761346.1 DIP1984 family protein -
KQ251_RS19800 (KQ251_19725) 7172..7381 - 210 WP_000069474.1 hypothetical protein -
KQ251_RS19805 (KQ251_19730) 7374..7676 - 303 WP_001129974.1 XRE family transcriptional regulator -
KQ251_RS19810 (KQ251_19735) 7669..8025 - 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11204 11204


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T206482 WP_000438826.1 NZ_CP076806:2953-3240 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T206482 NZ_CP102439:c177287-176844 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT206482 WP_001983304.1 NZ_CP076806:3227-3541 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT206482 NZ_CP102439:c177514-177284 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References