206480

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3193363..3194016 Replicon chromosome
Accession NZ_CP076804
Organism Acinetobacter baumannii strain UC24371

Toxin (Protein)


Gene name cptA Uniprot ID A0A009I802
Locus tag KQ251_RS15290 Protein ID WP_000607076.1
Coordinates 3193363..3193752 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KQ251_RS15295 Protein ID WP_001288210.1
Coordinates 3193759..3194016 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ251_RS15275 (KQ251_15205) 3188481..3190676 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
KQ251_RS15280 (KQ251_15210) 3190864..3191430 - 567 WP_000651536.1 rhombosortase -
KQ251_RS15285 (KQ251_15215) 3191508..3192593 - 1086 WP_000049107.1 hypothetical protein -
KQ251_RS15290 (KQ251_15220) 3193363..3193752 - 390 WP_000607076.1 hypothetical protein Toxin
KQ251_RS15295 (KQ251_15225) 3193759..3194016 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
KQ251_RS15300 (KQ251_15230) 3194204..3195376 + 1173 WP_045900150.1 acyl-CoA dehydrogenase family protein -
KQ251_RS15305 (KQ251_15235) 3195425..3196915 - 1491 WP_045900148.1 NAD(P)/FAD-dependent oxidoreductase -
KQ251_RS15310 (KQ251_15240) 3197097..3197474 - 378 WP_001216380.1 50S ribosomal protein L17 -
KQ251_RS15315 (KQ251_15245) 3197493..3198500 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15598.85 Da        Isoelectric Point: 10.3889

>T206480 WP_000607076.1 NZ_CP076804:c3193752-3193363 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGNKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T206480 NZ_CP076804:c3193752-3193363 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTAATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT206480 WP_001288210.1 NZ_CP076804:c3194016-3193759 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT206480 NZ_CP076804:c3194016-3193759 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009I802

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References