Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 1708355..1709008 Replicon chromosome
Accession NZ_CP076801
Organism Acinetobacter baumannii strain UC25604

Toxin (Protein)


Gene name cptA Uniprot ID A0A009I802
Locus tag KQ252_RS08145 Protein ID WP_000607076.1
Coordinates 1708355..1708744 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KQ252_RS08150 Protein ID WP_001288210.1
Coordinates 1708751..1709008 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ252_RS08130 (KQ252_08115) 1703473..1705668 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
KQ252_RS08135 (KQ252_08120) 1705856..1706422 - 567 WP_000651536.1 rhombosortase -
KQ252_RS08140 (KQ252_08125) 1706500..1707585 - 1086 WP_000049107.1 hypothetical protein -
KQ252_RS08145 (KQ252_08130) 1708355..1708744 - 390 WP_000607076.1 hypothetical protein Toxin
KQ252_RS08150 (KQ252_08135) 1708751..1709008 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
KQ252_RS08155 (KQ252_08140) 1709196..1710368 + 1173 WP_045900150.1 acyl-CoA dehydrogenase family protein -
KQ252_RS08160 (KQ252_08145) 1710417..1711907 - 1491 WP_045900148.1 NAD(P)/FAD-dependent oxidoreductase -
KQ252_RS08165 (KQ252_08150) 1712089..1712466 - 378 WP_001216380.1 50S ribosomal protein L17 -
KQ252_RS08170 (KQ252_08155) 1712485..1713492 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15598.85 Da        Isoelectric Point: 10.3889

>T206477 WP_000607076.1 NZ_CP076801:c1708744-1708355 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGNKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T206477 NZ_CP102438:c4595618-4595085 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT206477 WP_001288210.1 NZ_CP076801:c1709008-1708751 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT206477 NZ_CP102438:c4595895-4595629 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAGTGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009I802

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References