Detailed information of TA system TA206476

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1452165..1452816
• Replicon: chromosome
• Accession: NZ_CP076742
• Organism: Acinetobacter baumannii strain X4-705

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A5Q0RPK1
• Locus tag: KRO89_RS06925
• Protein ID: WP_000838147.1
• Coordinates: 1452165..1452347 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: L9LVK3
• Locus tag: KRO89_RS06930
• Protein ID: WP_002053018.1
• Coordinates: 1452412..1452816 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KRO89_RS06880 (KRO89_06855)	1447498..1447866	+	369	WP_025467978.1	hypothetical protein	-
KRO89_RS06885 (KRO89_06860)	1447922..1448341	+	420	WP_002053092.1	hypothetical protein	-
KRO89_RS06890 (KRO89_06865)	1448341..1448793	+	453	WP_002053117.1	hypothetical protein	-
KRO89_RS06895 (KRO89_06870)	1448857..1449270	+	414	WP_031965420.1	hypothetical protein	-
KRO89_RS06900 (KRO89_06875)	1449236..1449604	+	369	WP_001983390.1	hypothetical protein	-
KRO89_RS06905 (KRO89_06880)	1449606..1450004	+	399	WP_030423713.1	phage tail terminator-like protein	-
KRO89_RS06910 (KRO89_06885)	1450006..1450218	+	213	WP_030423712.1	hypothetical protein	-
KRO89_RS06915 (KRO89_06890)	1450326..1451255	+	930	WP_049594449.1	phage tail tube protein	-
KRO89_RS06920 (KRO89_06895)	1451300..1451833	+	534	WP_057691629.1	hypothetical protein	-
KRO89_RS06925 (KRO89_06900)	1452165..1452347	+	183	WP_000838147.1	type II toxin-antitoxin system HicA family toxin	Toxin
KRO89_RS06930 (KRO89_06905)	1452412..1452816	+	405	WP_002053018.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KRO89_RS06935 (KRO89_06910)	1452912..1453430	+	519	WP_005070358.1	DUF4468 domain-containing protein	-
KRO89_RS06940 (KRO89_06915)	1453527..1457498	+	3972	WP_279446913.1	tape measure protein	-
KRO89_RS06945 (KRO89_06920)	1457538..1457681	+	144	WP_164523119.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1421709..1469696	47987

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6682.88 Da
• Isoelectric Point: 10.6602

>T206476 WP_000838147.1 NZ_CP076742:1452165-1452347 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Nucleotide

• Length: 183 bp

>T206476 NZ_CP102438:3991156-3991374 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14660.69 Da
• Isoelectric Point: 4.4289

>AT206476 WP_002053018.1 NZ_CP076742:1452412-1452816 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT206476 NZ_CP102438:3990755-3991129 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: A0A5Q0RPK1

Antitoxin

• AlphaFold DB: A0A5Q0RVR6