Detailed information of TA system TA206472

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2790819..2791470
• Replicon: chromosome
• Accession: NZ_CP076739
• Organism: Acinetobacter baumannii strain X4-584

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A5Q0RPK1
• Locus tag: KRO88_RS13540
• Protein ID: WP_000838147.1
• Coordinates: 2791288..2791470 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: L9LVK3
• Locus tag: KRO88_RS13535
• Protein ID: WP_002053018.1
• Coordinates: 2790819..2791223 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KRO88_RS13520 (KRO88_13420)	2785954..2786097	-	144	WP_164523119.1	hypothetical protein	-
KRO88_RS13525 (KRO88_13425)	2786137..2790108	-	3972	WP_279446913.1	tape measure protein	-
KRO88_RS13530 (KRO88_13430)	2790205..2790723	-	519	WP_005070358.1	DUF4468 domain-containing protein	-
KRO88_RS13535 (KRO88_13435)	2790819..2791223	-	405	WP_002053018.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KRO88_RS13540 (KRO88_13440)	2791288..2791470	-	183	WP_000838147.1	type II toxin-antitoxin system HicA family toxin	Toxin
KRO88_RS13545 (KRO88_13445)	2791802..2792335	-	534	WP_057691629.1	hypothetical protein	-
KRO88_RS13550 (KRO88_13450)	2792380..2793309	-	930	WP_049594449.1	phage tail tube protein	-
KRO88_RS13555 (KRO88_13455)	2793417..2793629	-	213	WP_030423712.1	hypothetical protein	-
KRO88_RS13560 (KRO88_13460)	2793631..2794029	-	399	WP_030423713.1	phage tail terminator-like protein	-
KRO88_RS13565 (KRO88_13465)	2794031..2794399	-	369	WP_001983390.1	hypothetical protein	-
KRO88_RS13570 (KRO88_13470)	2794365..2794778	-	414	WP_031965420.1	hypothetical protein	-
KRO88_RS13575 (KRO88_13475)	2794842..2795294	-	453	WP_002053117.1	hypothetical protein	-
KRO88_RS13580 (KRO88_13480)	2795294..2795713	-	420	WP_002053092.1	hypothetical protein	-
KRO88_RS13585 (KRO88_13485)	2795769..2796137	-	369	WP_025467978.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2773939..2822197	48258

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6682.88 Da
• Isoelectric Point: 10.6602

>T206472 WP_000838147.1 NZ_CP076739:c2791470-2791288 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Nucleotide

• Length: 183 bp

>T206472 NZ_CP102438:359745-360092 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14660.69 Da
• Isoelectric Point: 4.4289

>AT206472 WP_002053018.1 NZ_CP076739:c2791223-2790819 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT206472 NZ_CP102438:360092-360391 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: A0A5Q0RPK1

Antitoxin

• AlphaFold DB: A0A5Q0RVR6