Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1910862..1911513 | Replicon | chromosome |
| Accession | NZ_CP076736 | ||
| Organism | Acinetobacter baumannii strain X4-201 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A5Q0RPK1 |
| Locus tag | KRO90_RS09110 | Protein ID | WP_000838147.1 |
| Coordinates | 1910862..1911044 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | L9LVK3 |
| Locus tag | KRO90_RS09115 | Protein ID | WP_002053018.1 |
| Coordinates | 1911109..1911513 (+) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KRO90_RS09065 (KRO90_09015) | 1906195..1906563 | + | 369 | WP_025467978.1 | hypothetical protein | - |
| KRO90_RS09070 (KRO90_09020) | 1906619..1907038 | + | 420 | WP_002053092.1 | hypothetical protein | - |
| KRO90_RS09075 (KRO90_09025) | 1907038..1907490 | + | 453 | WP_002053117.1 | hypothetical protein | - |
| KRO90_RS09080 (KRO90_09030) | 1907554..1907967 | + | 414 | WP_031965420.1 | hypothetical protein | - |
| KRO90_RS09085 (KRO90_09035) | 1907933..1908301 | + | 369 | WP_001983390.1 | hypothetical protein | - |
| KRO90_RS09090 (KRO90_09040) | 1908303..1908701 | + | 399 | WP_030423713.1 | phage tail terminator-like protein | - |
| KRO90_RS09095 (KRO90_09045) | 1908703..1908915 | + | 213 | WP_030423712.1 | hypothetical protein | - |
| KRO90_RS09100 (KRO90_09050) | 1909023..1909952 | + | 930 | WP_049594449.1 | phage tail tube protein | - |
| KRO90_RS09105 (KRO90_09055) | 1909997..1910530 | + | 534 | WP_057691629.1 | hypothetical protein | - |
| KRO90_RS09110 (KRO90_09060) | 1910862..1911044 | + | 183 | WP_000838147.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KRO90_RS09115 (KRO90_09065) | 1911109..1911513 | + | 405 | WP_002053018.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KRO90_RS09120 (KRO90_09070) | 1911609..1912127 | + | 519 | WP_005070358.1 | DUF4468 domain-containing protein | - |
| KRO90_RS09125 (KRO90_09075) | 1912224..1916195 | + | 3972 | WP_279446913.1 | tape measure protein | - |
| KRO90_RS09130 (KRO90_09080) | 1916235..1916378 | + | 144 | WP_164523119.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1880407..1928396 | 47989 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6682.88 Da Isoelectric Point: 10.6602
>T206470 WP_000838147.1 NZ_CP076736:1910862-1911044 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK
Download Length: 183 bp
>T206470 NZ_CP102438:201532-202017 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAACCAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAACCAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14660.69 Da Isoelectric Point: 4.4289
>AT206470 WP_002053018.1 NZ_CP076736:1911109-1911513 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT206470 NZ_CP102438:201278-201544 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAGCTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAGCTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q0RPK1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q0RVR6 |