Detailed information of TA system TA206468

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 133204..134926
• Replicon: chromosome
• Accession: NZ_CP076733
• Organism: Photobacterium damselae strain Pdd2008

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: KQY33_RS00645
• Protein ID: WP_284633893.1
• Coordinates: 133988..134926 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: KQY33_RS00640
• Protein ID: WP_017043869.1
• Coordinates: 133204..133995 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQY33_RS00615 (KQY33_00615)	129434..129709	-	276	WP_005302516.1	DNA-directed RNA polymerase subunit omega	-
KQY33_RS00620 (KQY33_00620)	129762..130388	-	627	WP_065172456.1	guanylate kinase	-
KQY33_RS00625 (KQY33_00625)	130734..130958	-	225	WP_017043872.1	hypothetical protein	-
KQY33_RS00630 (KQY33_00630)	130959..131243	-	285	WP_017043871.1	helix-turn-helix domain-containing protein	-
KQY33_RS00635 (KQY33_00635)	131240..132934	-	1695	WP_017043870.1	DUF927 domain-containing protein	-
KQY33_RS00640 (KQY33_00640)	133204..133995	+	792	WP_017043869.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KQY33_RS00645 (KQY33_00645)	133988..134926	+	939	WP_284633893.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KQY33_RS00650 (KQY33_00650)	134965..137085	+	2121	WP_284633894.1	DNA methyltransferase	-
KQY33_RS00655 (KQY33_00655)	137089..139689	+	2601	WP_284633895.1	DEAD/DEAH box helicase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35386.56 Da
• Isoelectric Point: 4.8348

>T206468 WP_284633893.1 NZ_CP076733:133988-134926 [Photobacterium damselae]
MDRESPYYKQVSLLIRMLPVVATEPSFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRNEALANVKAALQRITDLINKE
PENRAVLQDHRLDELRIVVTSPNATIKIEVSPVARGTLHKPNSLAVQESVEEEFGYAEIPVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLAEEGISRDIFVGFITYVLSHPRPINEVMAPNWQPLDDKFQAEFDGMTFEPVELNDLISIRPAMVAALQA
HFTEKDRSFLLSFKQGNPDWSLFDYPDAAELPAIRWKLQNIAKLAKNQEKHVEQLTKLESVLDEWLKQANSN

Nucleotide

• Length: 939 bp

>T206468 NZ_CP102436:c166707-166264 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 29968.07 Da
• Isoelectric Point: 9.6742

>AT206468 WP_017043869.1 NZ_CP076733:133204-133995 [Photobacterium damselae]
MSSKINWLVANAYPGALVLQQWLTENGISYSLAQKYAQSGWLRKLSSGVYYRPSARDDVKPGWVDALQAMDTQLHHRVHL
AGLSSLTHQGLSHYLQFSKEQVWIGVKNKQSLPKWFREFPNQNWFYCGNHKLEAVSDKDLKVITVKGKELKASCPELAAY
EVVDAIGKQISFEHAAELFQGLVNLSPRKVQSLLERSSSVQTNRVFLFLSHYHGHQWTQRIDETKIALGSGKRQVVEQGR
FDERYQITVPEILSVKKEEANNG

Nucleotide

• Length: 792 bp

>AT206468 NZ_CP102436:c166934-166704 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA