Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2302082..2303057 Replicon chromosome
Accession NZ_CP076728
Organism Bacillus anthracis strain Tyrol 3520

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KRO24_RS12070 Protein ID WP_002036394.1
Coordinates 2302082..2302819 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KRO24_RS12075 Protein ID WP_000588712.1
Coordinates 2302932..2303057 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRO24_RS12050 (KRO24_12030) 2297810..2298592 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KRO24_RS12055 (KRO24_12035) 2298714..2300399 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KRO24_RS12060 (KRO24_12040) 2300506..2300988 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KRO24_RS12065 (KRO24_12045) 2301156..2301893 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KRO24_RS12070 (KRO24_12050) 2302082..2302819 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KRO24_RS12075 (KRO24_12055) 2302932..2303057 + 126 WP_000588712.1 hypothetical protein Antitoxin
KRO24_RS12080 (KRO24_12060) 2303080..2303310 + 231 WP_011053163.1 stage II sporulation protein SB -
KRO24_RS12085 (KRO24_12065) 2303347..2303628 - 282 WP_001041555.1 hypothetical protein -
KRO24_RS12090 (KRO24_12070) 2303905..2304141 - 237 WP_001021688.1 hypothetical protein -
KRO24_RS28720 2304278..2304403 + 126 WP_000694311.1 hypothetical protein -
KRO24_RS12095 (KRO24_12075) 2304480..2304656 + 177 WP_000808045.1 stage II sporulation protein SB -
KRO24_RS12100 (KRO24_12080) 2304800..2306269 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KRO24_RS12105 (KRO24_12085) 2306833..2307303 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T206465 WP_002036394.1 NZ_CP076728:2302082-2302819 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T206465 NZ_CP102435:c5057561-5057178 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT206465 WP_000588712.1 NZ_CP076728:2302932-2303057 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT206465 NZ_CP102435:c5057803-5057561 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References