Detailed information of TA system TA206462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2919725..2920269
• Replicon: chromosome
• Accession: NZ_CP076726
• Organism: Xanthomonas arboricola pv. juglandis strain IVIA 2499

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KP728_RS12625
• Protein ID: WP_228960823.1
• Coordinates: 2920000..2920269 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2N7V9L6
• Locus tag: KP728_RS12620
• Protein ID: WP_016902922.1
• Coordinates: 2919725..2919982 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP728_RS12605 (KP728_12530)	2914833..2916341	-	1509	WP_016904858.1	ribonuclease H-like domain-containing protein	-
KP728_RS12610 (KP728_12535)	2916338..2918833	-	2496	WP_016904859.1	DEAD/DEAH box helicase	-
KP728_RS12615 (KP728_12540)	2919007..2919669	+	663	WP_039511099.1	hemolysin III family protein	-
KP728_RS12620 (KP728_12545)	2919725..2919982	+	258	WP_016902922.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KP728_RS12625 (KP728_12550)	2920000..2920269	+	270	WP_228960823.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KP728_RS12630 (KP728_12555)	2920388..2920909	-	522	WP_016902924.1	hypothetical protein	-
KP728_RS12635 (KP728_12560)	2921079..2921432	-	354	WP_016902925.1	helix-turn-helix domain-containing protein	-
KP728_RS12640 (KP728_12565)	2921455..2921673	+	219	WP_230673957.1	YciI family protein	-
KP728_RS12645 (KP728_12570)	2921833..2922924	-	1092	WP_053051698.1	ATP-grasp fold amidoligase family protein	-
KP728_RS12650 (KP728_12575)	2923380..2924093	+	714	WP_053046149.1	hypothetical protein	-
KP728_RS12655 (KP728_12580)	2924104..2924997	-	894	WP_053046150.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2919725..2942477	22752

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10221.75 Da
• Isoelectric Point: 10.1539

>T206462 WP_228960823.1 NZ_CP076726:2920000-2920269 [Xanthomonas arboricola pv. juglandis]
VADLDAIADYIALEDAAAAAALVRRVFAHVEQLAEHPESGSRPQELKRSRYRQIVEPPCRVFYRVDGQRVVVVHVMRSER
LLRKNRLSR

Nucleotide

• Length: 270 bp

>T206462 NZ_CP102435:c4467044-4466676 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9704.23 Da
• Isoelectric Point: 8.6056

>AT206462 WP_016902922.1 NZ_CP076726:2919725-2919982 [Xanthomonas arboricola pv. juglandis]
MRTELVTTLKRQATELLADVERDKEPILITQHGLPSAYLVDVASYERMQQRMAILEGIARGEMAVAEGRSLSHEQAKQRL
ARWLK

Nucleotide

• Length: 258 bp

>AT206462 NZ_CP102435:c4467262-4467041 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2N7V9L6