Detailed information of TA system TA206460

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 5235339..5235883
• Replicon: chromosome
• Accession: NZ_CP076725
• Organism: Xanthomonas arboricola pv. juglandis strain IVIA 1317

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KP727_RS22385
• Protein ID: WP_228960823.1
• Coordinates: 5235339..5235608 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2N7V9L6
• Locus tag: KP727_RS22390
• Protein ID: WP_016902922.1
• Coordinates: 5235626..5235883 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP727_RS22355 (KP727_22265)	5230611..5231504	+	894	WP_053046150.1	LysR family transcriptional regulator	-
KP727_RS22360 (KP727_22270)	5231515..5232228	-	714	WP_053046149.1	hypothetical protein	-
KP727_RS22365 (KP727_22275)	5232684..5233775	+	1092	WP_053051698.1	ATP-grasp fold amidoligase family protein	-
KP727_RS22370 (KP727_22280)	5233935..5234153	-	219	WP_230673957.1	YciI family protein	-
KP727_RS22375 (KP727_22285)	5234176..5234529	+	354	WP_016902925.1	helix-turn-helix domain-containing protein	-
KP727_RS22380 (KP727_22290)	5234699..5235220	+	522	WP_016902924.1	hypothetical protein	-
KP727_RS22385 (KP727_22295)	5235339..5235608	-	270	WP_228960823.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KP727_RS22390 (KP727_22300)	5235626..5235883	-	258	WP_016902922.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KP727_RS22395 (KP727_22305)	5235939..5236601	-	663	WP_039511099.1	hemolysin III family protein	-
KP727_RS22400 (KP727_22310)	5236775..5239270	+	2496	WP_016904859.1	DEAD/DEAH box helicase	-
KP727_RS22405 (KP727_22315)	5239267..5240775	+	1509	WP_016904858.1	ribonuclease H-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5213454..5235883	22429

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10221.75 Da
• Isoelectric Point: 10.1539

>T206460 WP_228960823.1 NZ_CP076725:c5235608-5235339 [Xanthomonas arboricola pv. juglandis]
VADLDAIADYIALEDAAAAAALVRRVFAHVEQLAEHPESGSRPQELKRSRYRQIVEPPCRVFYRVDGQRVVVVHVMRSER
LLRKNRLSR

Nucleotide

• Length: 270 bp

>T206460 NZ_CP102435:c4057928-4057443 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9704.23 Da
• Isoelectric Point: 8.6056

>AT206460 WP_016902922.1 NZ_CP076725:c5235883-5235626 [Xanthomonas arboricola pv. juglandis]
MRTELVTTLKRQATELLADVERDKEPILITQHGLPSAYLVDVASYERMQQRMAILEGIARGEMAVAEGRSLSHEQAKQRL
ARWLK

Nucleotide

• Length: 258 bp

>AT206460 NZ_CP102435:c4058218-4057925 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2N7V9L6