Detailed information of TA system TA206452

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1955872..1956497
• Replicon: chromosome
• Accession: NZ_CP076721
• Organism: Streptococcus parasuis strain H35

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KQ224_RS10125
• Protein ID: WP_171989763.1
• Coordinates: 1956159..1956497 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: KQ224_RS10120
• Protein ID: WP_130554939.1
• Coordinates: 1955872..1956159 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ224_RS10090 (KQ224_10090)	1951270..1951710	-	441	WP_130554934.1	MarR family winged helix-turn-helix transcriptional regulator	-
KQ224_RS10095 (KQ224_10095)	1951857..1952354	+	498	WP_216806575.1	DUF5590 domain-containing protein	-
KQ224_RS10100 (KQ224_10100)	1952351..1953532	+	1182	WP_216806576.1	pyridoxal phosphate-dependent aminotransferase	-
KQ224_RS10105 (KQ224_10105)	1953547..1954893	+	1347	WP_216806577.1	asparagine--tRNA ligase	-
KQ224_RS10110 (KQ224_10110)	1955231..1955458	+	228	WP_130554954.1	DUF6290 family protein	-
KQ224_RS10115 (KQ224_10115)	1955448..1955717	+	270	WP_105127516.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KQ224_RS10120 (KQ224_10120)	1955872..1956159	+	288	WP_130554939.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KQ224_RS10125 (KQ224_10125)	1956159..1956497	+	339	WP_171989763.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQ224_RS10130 (KQ224_10130)	1956478..1956681	+	204	WP_216806578.1	LPXTG cell wall anchor domain-containing protein	-
KQ224_RS10135 (KQ224_10135)	1956976..1958295	+	1320	WP_174845779.1	MATE family efflux transporter	-
KQ224_RS10140 (KQ224_10140)	1958345..1958725	+	381	WP_174845778.1	RidA family protein	-
KQ224_RS10145 (KQ224_10145)	1958748..1959635	+	888	WP_174845777.1	RNase adapter RapZ	-
KQ224_RS10150 (KQ224_10150)	1959632..1960606	+	975	WP_174845776.1	YvcK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-106)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (10-81)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12914.84 Da
• Isoelectric Point: 5.9262

>T206452 WP_171989763.1 NZ_CP076721:1956159-1956497 [Streptococcus parasuis]
MEKYRVIISPKLIEQIKSIRDYVANVKLSPETAERLVTAIFDEIESLELFPERGFDADEKIGVKIDKNGRSSRGITIQNG
KYIVIYTVNQEEHLVEVAFLFSSKTDYAKLFR

Nucleotide

• Length: 339 bp

>T206452 NZ_CP102434:c1346763-1346485 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAACGTAGAAAACTTGCTAGAGCAGCTTCTTATGGGTGTACAGCGAGACGGTG
TTCGTGGGCGATTACTTATAATTCCTGAGATTTCGATGATCGTCTCCTATTGGATCGAAGGCGACATTATCCGAATCATG
CGCGTACTCCACCAGAAACAAAAATTTCCTATGGATTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10811.34 Da
• Isoelectric Point: 4.7494

>AT206452 WP_130554939.1 NZ_CP076721:1955872-1956159 [Streptococcus parasuis]
MPTVIRDKQINFKVNSEYFELAKVVFQENGLDITSAFNEFVQEVAISKTLPFKTVEEKEREKLIARLQEEVSTSYEALKA
DKGLSVEEARKAVLG

Nucleotide

• Length: 288 bp

>AT206452 NZ_CP102434:c1347044-1346760 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
ACTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAATCATTATCTCACGATGCGTGGTTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCAA
ATGGAAGAACGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA