Detailed information of TA system TA206451

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1955231..1955717
• Replicon: chromosome
• Accession: NZ_CP076721
• Organism: Streptococcus parasuis strain H35

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KQ224_RS10115
• Protein ID: WP_105127516.1
• Coordinates: 1955448..1955717 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KQ224_RS10110
• Protein ID: WP_130554954.1
• Coordinates: 1955231..1955458 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ224_RS10085 (KQ224_10085)	1950682..1951194	-	513	WP_216806574.1	NAD(P)H-dependent oxidoreductase	-
KQ224_RS10090 (KQ224_10090)	1951270..1951710	-	441	WP_130554934.1	MarR family winged helix-turn-helix transcriptional regulator	-
KQ224_RS10095 (KQ224_10095)	1951857..1952354	+	498	WP_216806575.1	DUF5590 domain-containing protein	-
KQ224_RS10100 (KQ224_10100)	1952351..1953532	+	1182	WP_216806576.1	pyridoxal phosphate-dependent aminotransferase	-
KQ224_RS10105 (KQ224_10105)	1953547..1954893	+	1347	WP_216806577.1	asparagine--tRNA ligase	-
KQ224_RS10110 (KQ224_10110)	1955231..1955458	+	228	WP_130554954.1	DUF6290 family protein	Antitoxin
KQ224_RS10115 (KQ224_10115)	1955448..1955717	+	270	WP_105127516.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQ224_RS10120 (KQ224_10120)	1955872..1956159	+	288	WP_130554939.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
KQ224_RS10125 (KQ224_10125)	1956159..1956497	+	339	WP_171989763.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KQ224_RS10130 (KQ224_10130)	1956478..1956681	+	204	WP_216806578.1	LPXTG cell wall anchor domain-containing protein	-
KQ224_RS10135 (KQ224_10135)	1956976..1958295	+	1320	WP_174845779.1	MATE family efflux transporter	-
KQ224_RS10140 (KQ224_10140)	1958345..1958725	+	381	WP_174845778.1	RidA family protein	-
KQ224_RS10145 (KQ224_10145)	1958748..1959635	+	888	WP_174845777.1	RNase adapter RapZ	-
KQ224_RS10150 (KQ224_10150)	1959632..1960606	+	975	WP_174845776.1	YvcK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10469.51 Da
• Isoelectric Point: 10.4241

>T206451 WP_105127516.1 NZ_CP076721:1955448-1955717 [Streptococcus parasuis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEM
GHRKDIYRK

Nucleotide

• Length: 270 bp

>T206451 NZ_CP102434:c1341045-1340767 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAGAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTAAACAACCTTTAATGGGTGTGCAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGAGTTATG
CGTGTACAACACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8522.62 Da
• Isoelectric Point: 4.1707

>AT206451 WP_130554954.1 NZ_CP076721:1955231-1955458 [Streptococcus parasuis]
MGIVSLRLNETEEEIFRSYAIHTGKSLSELFKSALIEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Nucleotide

• Length: 228 bp

>AT206451 NZ_CP102434:c1341326-1341042 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCCTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA