206450

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1941286..1942523 Replicon chromosome
Accession NZ_CP076721
Organism Streptococcus parasuis strain H35

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag KQ224_RS10060 Protein ID WP_216806569.1
Coordinates 1941762..1942523 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag KQ224_RS10055 Protein ID WP_216806568.1
Coordinates 1941286..1941762 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ224_RS10030 (KQ224_10030) 1937494..1937850 + 357 WP_024404952.1 type II toxin-antitoxin system MqsR family toxin -
KQ224_RS10035 (KQ224_10035) 1937871..1938836 + 966 WP_216806565.1 DUF4065 domain-containing protein -
KQ224_RS10040 (KQ224_10040) 1939155..1939319 - 165 WP_216806566.1 hypothetical protein -
KQ224_RS11595 1939319..1939417 - 99 Protein_1947 type II toxin-antitoxin system PemK/MazF family toxin -
KQ224_RS10045 (KQ224_10045) 1939407..1939622 - 216 Protein_1948 AbrB family transcriptional regulator -
KQ224_RS10050 (KQ224_10050) 1939849..1941156 + 1308 WP_216806567.1 hypothetical protein -
KQ224_RS10055 (KQ224_10055) 1941286..1941762 + 477 WP_216806568.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
KQ224_RS10060 (KQ224_10060) 1941762..1942523 + 762 WP_216806569.1 type II toxin-antitoxin system toxin PezT Toxin
KQ224_RS10065 (KQ224_10065) 1942672..1946160 + 3489 WP_216806570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29035.85 Da        Isoelectric Point: 5.2673

>T206450 WP_216806569.1 NZ_CP076721:1941762-1942523 [Streptococcus parasuis]
MRLEEFSEAEFQKALQRTIRVLTRGKTISDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRFQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRKTAQLLASKGYQVFLAIIGTKPELSFLSTLIRYEE
LYAIDPNQARATPKEHHDEIVENLVDNLRELEREQLFDCIQIYQRDRTCIYDSETDEGSAAEVLQNCLFGEWSKVEEEML
KAGQERLREFGEK

Download         Length: 762 bp

>T206450 NZ_CP102430:84440-84739 [Pseudomonas psychrotolerans]
ATGAAAGAGAAAATTTTCGACTACGATCCCGCCGATGCCCTCACGGACCCGGCGTCCATCGCTGTCTTCCTGGAAGACGC
TTTCGAGACTGGCGACGCCGCCTACATCGCCAAGGCCCTGGGCGTTGTCGCCCGTGCCAAAGGGATGGGTGAGATTGCCA
AGGAATCGGGCTTGTCCCGTGAAAACCTGTACCGCTCGTTTTCAGAAAACGGCAATCCGACCCTGAAAACCATGTTGGCC
GTCATGCAGGCTGTCGGCCTGGATCTGACTGCCCGCGTCCATATCACTCCAGCACACTAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18236.60 Da        Isoelectric Point: 4.4750

>AT206450 WP_216806568.1 NZ_CP076721:1941286-1941762 [Streptococcus parasuis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELIHTKIYLVDTFDEIERYNGYLDGIERVLDMAHHRVVA

Download         Length: 477 bp

>AT206450 NZ_CP102430:84141-84443 [Pseudomonas psychrotolerans]
ATGAAAACGATTAAACAAACCGCCACTTTCAGGAACTGGGAACGCAAGCTGAAAGACAAGCAGGCGAAAGCAATCATCGC
TGCGCGGGTCTTTCGGGTTGCGAACGGATTGCTCGGTGATGTCCAGCCAGTCGGCCAGGGCATCAGCGAACTCCGCATTC
ATCATGGTCCCGGCTATCGTGTGTATTTTCAGCAGCGCGGGAACCAGCTGGTCCTGTTGTTGTGTGGTGGAGACAAAAGC
AGCCAAGCGCGGGACATCGAGACCGCCAAAGCACTGGCCAGCCAGTGGAGTGATGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References