206449

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1903412..1904081 Replicon chromosome
Accession NZ_CP076721
Organism Streptococcus parasuis strain H35

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KQ224_RS09890 Protein ID WP_216806543.1
Coordinates 1903412..1903594 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KQ224_RS09895 Protein ID WP_160863757.1
Coordinates 1903632..1904081 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ224_RS09860 (KQ224_09860) 1898637..1899104 + 468 WP_216806539.1 SsrA-binding protein SmpB -
KQ224_RS09865 (KQ224_09865) 1899195..1900523 - 1329 WP_043026189.1 PH domain-containing protein -
KQ224_RS09870 (KQ224_09870) 1900523..1900960 - 438 WP_041179201.1 hypothetical protein -
KQ224_RS09875 (KQ224_09875) 1901063..1901215 - 153 WP_216806540.1 aureocin A53 family class IId bacteriocin -
KQ224_RS09880 (KQ224_09880) 1901421..1902104 + 684 WP_216806541.1 hypothetical protein -
KQ224_RS09885 (KQ224_09885) 1902106..1902963 + 858 WP_216806542.1 ABC transporter ATP-binding protein -
KQ224_RS09890 (KQ224_09890) 1903412..1903594 + 183 WP_216806543.1 type II toxin-antitoxin system HicA family toxin Toxin
KQ224_RS09895 (KQ224_09895) 1903632..1904081 + 450 WP_160863757.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KQ224_RS09900 (KQ224_09900) 1904241..1905284 - 1044 WP_216806544.1 alcohol dehydrogenase catalytic domain-containing protein -
KQ224_RS09905 (KQ224_09905) 1905537..1906394 + 858 WP_216806545.1 SAM-dependent methyltransferase TehB -
KQ224_RS09910 (KQ224_09910) 1906489..1908951 + 2463 WP_216806546.1 heavy metal translocating P-type ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-113)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6693.90 Da        Isoelectric Point: 10.8207

>T206449 WP_216806543.1 NZ_CP076721:1903412-1903594 [Streptococcus parasuis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIHHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T206449 NZ_CP102430:84141-84443 [Pseudomonas psychrotolerans]
ATGAAAACGATTAAACAAACCGCCACTTTCAGGAACTGGGAACGCAAGCTGAAAGACAAGCAGGCGAAAGCAATCATCGC
TGCGCGGGTCTTTCGGGTTGCGAACGGATTGCTCGGTGATGTCCAGCCAGTCGGCCAGGGCATCAGCGAACTCCGCATTC
ATCATGGTCCCGGCTATCGTGTGTATTTTCAGCAGCGCGGGAACCAGCTGGTCCTGTTGTTGTGTGGTGGAGACAAAAGC
AGCCAAGCGCGGGACATCGAGACCGCCAAAGCACTGGCCAGCCAGTGGAGTGATGACGAATGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16639.64 Da        Isoelectric Point: 3.9790

>AT206449 WP_160863757.1 NZ_CP076721:1903632-1904081 [Streptococcus parasuis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RDEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 450 bp

>AT206449 NZ_CP102430:84440-84739 [Pseudomonas psychrotolerans]
ATGAAAGAGAAAATTTTCGACTACGATCCCGCCGATGCCCTCACGGACCCGGCGTCCATCGCTGTCTTCCTGGAAGACGC
TTTCGAGACTGGCGACGCCGCCTACATCGCCAAGGCCCTGGGCGTTGTCGCCCGTGCCAAAGGGATGGGTGAGATTGCCA
AGGAATCGGGCTTGTCCCGTGAAAACCTGTACCGCTCGTTTTCAGAAAACGGCAATCCGACCCTGAAAACCATGTTGGCC
GTCATGCAGGCTGTCGGCCTGGATCTGACTGCCCGCGTCCATATCACTCCAGCACACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References