Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Xre-MNT/HTH_26(antitoxin) |
| Location | 438973..440081 | Replicon | chromosome |
| Accession | NZ_CP076721 | ||
| Organism | Streptococcus parasuis strain H35 | ||
Toxin (Protein)
| Gene name | MNTss | Uniprot ID | A0A193AUR0 |
| Locus tag | KQ224_RS02205 | Protein ID | WP_002378351.1 |
| Coordinates | 438973..439842 (-) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | Xress | Uniprot ID | - |
| Locus tag | KQ224_RS02210 | Protein ID | WP_000205227.1 |
| Coordinates | 439857..440081 (-) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KQ224_RS02170 (KQ224_02170) | 434226..434660 | - | 435 | WP_002325146.1 | hypothetical protein | - |
| KQ224_RS11370 | 434694..434804 | - | 111 | Protein_431 | hypothetical protein | - |
| KQ224_RS02175 (KQ224_02175) | 434872..435330 | + | 459 | WP_002325145.1 | hypothetical protein | - |
| KQ224_RS02180 (KQ224_02180) | 435381..435632 | - | 252 | WP_002294510.1 | hypothetical protein | - |
| KQ224_RS02185 (KQ224_02185) | 435850..436659 | - | 810 | WP_002294509.1 | ANT(9) family aminoglycoside nucleotidyltransferase Spw | - |
| KQ224_RS02190 (KQ224_02190) | 436791..437318 | - | 528 | WP_002294507.1 | phosphoribosyltransferase family protein | - |
| KQ224_RS02195 (KQ224_02195) | 437362..438225 | - | 864 | WP_002294505.1 | aminoglycoside nucleotidyltransferase ANT(6)-Ia | - |
| KQ224_RS02200 (KQ224_02200) | 438258..438992 | - | 735 | WP_000662263.1 | class I SAM-dependent methyltransferase | - |
| KQ224_RS02205 (KQ224_02205) | 438973..439842 | - | 870 | WP_002378351.1 | nucleotidyltransferase domain-containing protein | Toxin |
| KQ224_RS02210 (KQ224_02210) | 439857..440081 | - | 225 | WP_000205227.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| KQ224_RS02215 (KQ224_02215) | 440224..440304 | - | 81 | Protein_440 | site-specific recombinase | - |
| KQ224_RS02220 (KQ224_02220) | 440685..441155 | + | 471 | WP_253952850.1 | hypothetical protein | - |
| KQ224_RS02225 (KQ224_02225) | 441219..443840 | - | 2622 | WP_174846041.1 | magnesium-translocating P-type ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | ant(6)-Ia | - | 436791..462232 | 25441 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 32912.50 Da Isoelectric Point: 4.7903
>T206448 WP_002378351.1 NZ_CP076721:c439842-438973 [Streptococcus parasuis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI
Download Length: 870 bp
>T206448 NZ_CP102430:35284-35583 [Pseudomonas psychrotolerans]
ATGAAAGAGAAAATTTTCGACTACGATCCCGCCGATGCCCTCACGGACCCGGCGTCCATCGCTGTCTTCCTGGAAGACGC
TTTCGAGACTGGCGACGCCGCCTACATCGCCAAGGCCCTGGGCGTTGTCGCCCGTGCCAAAGGGATGGGTGAGATTGCCA
AGGAATCGGGCTTGTCCCGTGAAAACCTGTACCGCTCGTTTTCAGAAAACGGCAATCCGACCCTGAAAACCATGTTGGCC
GTCATGCAGGCTGTCGGCCTGGATCTGACTGCCCGCGTCCATATCACTCCAGCACACTAA
ATGAAAGAGAAAATTTTCGACTACGATCCCGCCGATGCCCTCACGGACCCGGCGTCCATCGCTGTCTTCCTGGAAGACGC
TTTCGAGACTGGCGACGCCGCCTACATCGCCAAGGCCCTGGGCGTTGTCGCCCGTGCCAAAGGGATGGGTGAGATTGCCA
AGGAATCGGGCTTGTCCCGTGAAAACCTGTACCGCTCGTTTTCAGAAAACGGCAATCCGACCCTGAAAACCATGTTGGCC
GTCATGCAGGCTGTCGGCCTGGATCTGACTGCCCGCGTCCATATCACTCCAGCACACTAA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8365.68 Da Isoelectric Point: 4.5510
>AT206448 WP_000205227.1 NZ_CP076721:c440081-439857 [Streptococcus parasuis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE
Download Length: 225 bp
>AT206448 NZ_CP102430:34985-35287 [Pseudomonas psychrotolerans]
ATGAAAACGATTAAACAAACCGCCACTTTCAGGAACTGGGAACGCAAGCTGAAAGACAAGCAGGCGAAAGCAATCATCGC
TGCGCGGGTCTTTCGGGTTGCGAACGGATTGCTCGGTGATGTCCAGCCAGTCGGCCAGGGCATCAGCGAACTCCGCATTC
ATCATGGTCCCGGCTATCGTGTGTATTTTCAGCAGCGCGGGAACCAGCTGGTCCTGTTGTTGTGTGGTGGAGACAAAAGC
AGCCAAGCGCGGGACATCGAGACCGCCAAAGCACTGGCCAGCCAGTGGAGTGATGACGAATGA
ATGAAAACGATTAAACAAACCGCCACTTTCAGGAACTGGGAACGCAAGCTGAAAGACAAGCAGGCGAAAGCAATCATCGC
TGCGCGGGTCTTTCGGGTTGCGAACGGATTGCTCGGTGATGTCCAGCCAGTCGGCCAGGGCATCAGCGAACTCCGCATTC
ATCATGGTCCCGGCTATCGTGTGTATTTTCAGCAGCGCGGGAACCAGCTGGTCCTGTTGTTGTGTGGTGGAGACAAAAGC
AGCCAAGCGCGGGACATCGAGACCGCCAAAGCACTGGCCAGCCAGTGGAGTGATGACGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|