Detailed information of TA system TA206447

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 244698..245184
• Replicon: chromosome
• Accession: NZ_CP076721
• Organism: Streptococcus parasuis strain H35

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KQ224_RS01265
• Protein ID: WP_216806819.1
• Coordinates: 244927..245184 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KQ224_RS01260
• Protein ID: WP_216806818.1
• Coordinates: 244698..244937 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ224_RS01235 (KQ224_01235)	240028..241194	+	1167	WP_216806814.1	carbamoyl phosphate synthase large subunit	-
KQ224_RS01240 (KQ224_01240)	241333..241473	+	141	WP_171988482.1	hypothetical protein	-
KQ224_RS01245 (KQ224_01245)	241486..241875	+	390	WP_216806815.1	NisI/SpaI family lantibiotic immunity lipoprotein	-
KQ224_RS01250 (KQ224_01250)	241884..242636	+	753	WP_216806816.1	ABC transporter ATP-binding protein	-
KQ224_RS01255 (KQ224_01255)	242637..244607	+	1971	WP_216806817.1	FtsX-like permease family protein	-
KQ224_RS01260 (KQ224_01260)	244698..244937	+	240	WP_216806818.1	DUF6290 family protein	Antitoxin
KQ224_RS01265 (KQ224_01265)	244927..245184	+	258	WP_216806819.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQ224_RS01270 (KQ224_01270)	245223..245891	+	669	WP_171988476.1	response regulator transcription factor	-
KQ224_RS01275 (KQ224_01275)	245888..246829	+	942	WP_216806820.1	sensor histidine kinase	-
KQ224_RS01280 (KQ224_01280)	247010..248518	+	1509	WP_216806821.1	phosphomannomutase/phosphoglucomutase	-
KQ224_RS01285 (KQ224_01285)	248737..249807	-	1071	WP_216806822.1	tyrosine recombinase XerS	-
KQ224_RS01290 (KQ224_01290)	250051..250167	-	117	WP_216806823.1	EAL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	220406..282005	61599

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-75)

Antitoxin

• Protein of unknown function DUF6290 (1-75)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9824.47 Da
• Isoelectric Point: 10.7134

>T206447 WP_216806819.1 NZ_CP076721:244927-245184 [Streptococcus parasuis]
MSYKVILSAKVQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKVTVTSLKM
RNGSI

Nucleotide

• Length: 258 bp

>T206447 NZ_CP102430:34985-35287 [Pseudomonas psychrotolerans]
ATGAAAACGATTAAACAAACCGCCACTTTCAGGAACTGGGAACGCAAGCTGAAAGACAAGCAGGCGAAAGCAATCATCGC
TGCGCGGGTCTTTCGGGTTGCGAACGGATTGCTCGGTGATGTCCAGCCAGTCGGCCAGGGCATCAGCGAACTCCGCATTC
ATCATGGTCCCGGCTATCGTGTGTATTTTCAGCAGCGCGGGAACCAGCTGGTCCTGTTGTTGTGTGGTGGAGACAAAAGC
AGCCAAGCGCGGGACATCGAGACCGCCAAAGCACTGGCCAGCCAGTGGAGTGATGACGAATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8689.96 Da
• Isoelectric Point: 3.8548

>AT206447 WP_216806818.1 NZ_CP076721:244698-244937 [Streptococcus parasuis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLAALEDEYDARVADIALAEYQADLANGIEPITLEQMAEELGIEL

Nucleotide

• Length: 240 bp

>AT206447 NZ_CP102430:35284-35583 [Pseudomonas psychrotolerans]
ATGAAAGAGAAAATTTTCGACTACGATCCCGCCGATGCCCTCACGGACCCGGCGTCCATCGCTGTCTTCCTGGAAGACGC
TTTCGAGACTGGCGACGCCGCCTACATCGCCAAGGCCCTGGGCGTTGTCGCCCGTGCCAAAGGGATGGGTGAGATTGCCA
AGGAATCGGGCTTGTCCCGTGAAAACCTGTACCGCTCGTTTTCAGAAAACGGCAATCCGACCCTGAAAACCATGTTGGCC
GTCATGCAGGCTGTCGGCCTGGATCTGACTGCCCGCGTCCATATCACTCCAGCACACTAA