Detailed information of TA system TA206446

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-HTH_19
• Location: 72726..73969
• Replicon: chromosome
• Accession: NZ_CP076721
• Organism: Streptococcus parasuis strain H35

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: KQ224_RS00385
• Protein ID: WP_074392677.1
• Coordinates: 73202..73969 (+)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: KQ224_RS00380
• Protein ID: WP_074392676.1
• Coordinates: 72726..73202 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ224_RS00345 (KQ224_00345)	68204..68791	+	588	WP_216806722.1	HNH endonuclease	-
KQ224_RS00350 (KQ224_00350)	68815..69285	+	471	WP_105137247.1	SMI1/KNR4 family protein	-
KQ224_RS00355 (KQ224_00355)	69429..70022	+	594	WP_253952828.1	DNA/RNA non-specific endonuclease	-
KQ224_RS00360 (KQ224_00360)	70027..70476	+	450	WP_216806723.1	hypothetical protein	-
KQ224_RS00365 (KQ224_00365)	71105..71761	+	657	WP_216806724.1	DUF1524 domain-containing protein	-
KQ224_RS00370 (KQ224_00370)	71969..72310	+	342	Protein_75	DUF5945 family protein	-
KQ224_RS00375 (KQ224_00375)	72366..72656	+	291	WP_171841326.1	hypothetical protein	-
KQ224_RS00380 (KQ224_00380)	72726..73202	+	477	WP_074392676.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
KQ224_RS00385 (KQ224_00385)	73202..73969	+	768	WP_074392677.1	type II toxin-antitoxin system toxin PezT	Toxin
KQ224_RS00390 (KQ224_00390)	73970..76513	+	2544	WP_253952829.1	AAA family ATPase	-
KQ224_RS00395 (KQ224_00395)	76843..77202	+	360	WP_216806725.1	SAG1252 family conjugative relaxosome accessory protein	-
KQ224_RS00400 (KQ224_00400)	77212..77577	+	366	WP_216806726.1	MobC family plasmid mobilization relaxosome protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 29079.13 Da
• Isoelectric Point: 6.2547

>T206446 WP_074392677.1 NZ_CP076721:73202-73969 [Streptococcus parasuis]
MRLEEFSEADFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALKE
KYGKDSVDYTKGFAGKMVEHLVDELSMQGYHLLIEGTLRTTRVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESDKIFDRIQIYQRDRTCIYDSTIDEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK

Nucleotide

• Length: 768 bp

>T206446 NZ_CP102429:c21028-20618 [Pseudomonas psychrotolerans]
GTGACCACCTACATGCTCGATACCTGCATTTGCTCGTTCATCATGCGGGAGCATCCAGACGCCGTGATCAGGCGCCTTGT
TGCTGAGGTCGAGCGCGGTAACCGCATTGTGATTTCGGCCATCACCTACTCAGAAATGCGTTTCGGCCAGATCGGCAAGA
AGGCCTCACCCAAGCACAAGGTTCTGGTGGACGAGTTCGTTCGGCGATTGGATGCGGTGATCGCCTGGGATTTGCGCGCG
GTCGATGCGACGGTTGAGATCATGCGCCAGCTCAATGCGGCGGGTACACCGATCGGGTCGAACGATACCGCTATTGCTGG
GCATGCAATCGCTATCGGCTGCACCCTAGTGACCAACAATGTGCGTGAGTTCAGCCGGGTCCCCGGCCTCGTGTACGAAG
ACTGGGTTTGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18331.80 Da
• Isoelectric Point: 4.4813

>AT206446 WP_074392676.1 NZ_CP076721:72726-73202 [Streptococcus parasuis]
MIGDNIKSLRHTHDLTQPEFAKMLGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDILGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLFRYQDSQEIAFDDETNPWILMSDDLAELIHTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT206446 NZ_CP102429:c21255-21025 [Pseudomonas psychrotolerans]
ATGCGTACCGTATCGATTTTCATGAATGGCAGGAATCAAGCAGTCCGGCTGCCGCAGGACATGGCTTTTGAAGGCATCGG
CGAGCTTGAAATCTCCAAGGAGGGTGACGTCATCACCCTGCGGCCTGCTCGGCCTTCCTGGACGTCTCTGGCGGAACTGC
CTAAGGCTGACGCTGACTTCCTGCAGGAGCGCACGGCAGTGGCCAGTGATGAAGGCAGGTTCACTCTGTGA