Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 763974..764455 Replicon chromosome
Accession NZ_CP076706
Organism Escherichia coli O170:H18 strain CFIAFB20120266

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag KQ217_RS04025 Protein ID WP_101973497.1
Coordinates 764165..764455 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag KQ217_RS04020 Protein ID WP_216803715.1
Coordinates 763974..764165 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ217_RS24665 (759066) 759066..759185 - 120 Protein_784 hypothetical protein -
KQ217_RS03975 (759299) 759299..759571 - 273 Protein_785 ead/Ea22-like family protein -
KQ217_RS03980 (759568) 759568..759864 - 297 WP_216803708.1 DUF4406 domain-containing protein -
KQ217_RS03985 (759861) 759861..760178 - 318 WP_225915870.1 DNA-binding protein -
KQ217_RS03990 (760175) 760175..760897 - 723 WP_216803709.1 DUF1627 domain-containing protein -
KQ217_RS03995 (760919) 760919..761665 - 747 WP_216803710.1 ATP-binding protein -
KQ217_RS04000 (761672) 761672..762640 - 969 WP_216803711.1 helix-turn-helix domain-containing protein -
KQ217_RS04005 (762663) 762663..763088 - 426 WP_216803713.1 toxin YdaT family protein -
KQ217_RS04010 (763085) 763085..763348 - 264 WP_101973500.1 helix-turn-helix transcriptional regulator -
KQ217_RS04015 (763456) 763456..763956 + 501 WP_216803714.1 helix-turn-helix transcriptional regulator -
KQ217_RS04020 (763974) 763974..764165 + 192 WP_216803715.1 antitoxin Antitoxin
KQ217_RS04025 (764165) 764165..764455 + 291 WP_101973497.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQ217_RS04030 (764730) 764730..764882 + 153 WP_000367378.1 DUF1391 family protein -
KQ217_RS04035 (764894) 764894..765274 + 381 WP_216803716.1 hypothetical protein -
KQ217_RS04040 (765264) 765264..765485 - 222 WP_216803717.1 hypothetical protein -
KQ217_RS04045 (766047) 766047..766892 + 846 WP_216803718.1 Rha family phage regulatory protein -
KQ217_RS04050 (766909) 766909..767094 + 186 WP_216803719.1 host cell division inhibitory peptide Kil -
KQ217_RS04055 (767051) 767051..767215 + 165 WP_216803874.1 YdaE family protein -
KQ217_RS24670 (767296) 767296..767802 + 507 Protein_802 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ybtS / ybtX / ybtQ / ybtP 716716..780062 63346


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11143.97 Da        Isoelectric Point: 9.9855

>T206389 WP_101973497.1 NZ_CP076706:764165-764455 [Escherichia coli O170:H18]
MLPILWLPSARDDLRQIVAYIAKENPHAARRLKIRIETSVLSLTEHPYLYPPSERAPGLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKSC

Download         Length: 291 bp

>T206389 NZ_CP102379:2635687-2636760 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 6971.85 Da        Isoelectric Point: 4.1015

>AT206389 WP_216803715.1 NZ_CP076706:763974-764165 [Escherichia coli O170:H18]
MSTALSPIISEFETIEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMENLIAQIAATNRSV

Download         Length: 192 bp

>AT206389 NZ_CP102379:2636753-2637124 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References