Detailed information of TA system TA206380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 235386..236356
• Replicon: chromosome
• Accession: NZ_CP076706
• Organism: Escherichia coli O170:H18 strain CFIAFB20120266

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KQ217_RS01105
• Protein ID: WP_216803650.1
• Coordinates: 235386..236090 (-)
• Length: 235 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KQ217_RS01110
• Protein ID: WP_001334382.1
• Coordinates: 236090..236356 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ217_RS01090 (232781)	232781..233491	-	711	WP_033552824.1	fimbria/pilus periplasmic chaperone	-
KQ217_RS01095 (233853)	233853..234416	-	564	WP_033552812.1	type 1 fimbrial major subunit FimA	-
KQ217_RS01100 (234849)	234849..235115	-	267	Protein_218	AraC family transcriptional regulator	-
KQ217_RS01105 (235386)	235386..236090	-	705	WP_216803650.1	HipA domain-containing protein	Toxin
KQ217_RS01110 (236090)	236090..236356	-	267	WP_001334382.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KQ217_RS01115 (236664)	236664..236765	+	102	Protein_221	trans-aconitate 2-methyltransferase	-
KQ217_RS01120 (236760)	236760..237098	-	339	Protein_222	bestrophin family ion channel	-
KQ217_RS01125 (237295)	237295..238746	-	1452	WP_000854637.1	tagaturonate reductase	-
KQ217_RS01130 (238973)	238973..240391	-	1419	WP_000558456.1	diguanylate cyclase	-
KQ217_RS01135 (240530)	240530..240889	-	360	WP_001191031.1	DUF4186 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (18-195)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 235 a.a.
• Molecular weight: 26243.46 Da
• Isoelectric Point: 10.0358

>T206380 WP_216803650.1 NZ_CP076706:c236090-235386 [Escherichia coli O170:H18]
MPKLVTWMNNQRVGELTKAGRVRALAVERFDRRWNTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSS
EALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAI
DKIYPRHFLATAKVLKFPEVQMHEILSDFARMIPAALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Nucleotide

• Length: 705 bp

>T206380 NZ_CP076706:c236090-235386 [Escherichia coli O170:H18]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAAGCGGGAAGGGTGCGCGCGTTAGCGGT
CGAACGTTTTGACAGGCGTTGGAATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCG
GTTTACCTTCATCGGTGAAATATGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGC
GAGGCGCTGAAAGATCGCTATGATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAA
AAACTTCTCCGTATTTATTCAGGCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCC
TTGGCGGTACGGGAATACACATCAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATC
GATAAAATTTATCCGCGACATTTTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAG
TGACTTTGCCAGAATGATTCCGGCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGA
CGGCAGTTGAAACCAATGTGTTGAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10017.42 Da
• Isoelectric Point: 4.9632

>AT206380 WP_001334382.1 NZ_CP076706:c236356-236090 [Escherichia coli O170:H18]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT206380 NZ_CP076706:c236356-236090 [Escherichia coli O170:H18]
ATGATGAGCTTTCAGAAGATCTATAGCCCAATGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAATTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCAAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTGA