206337

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 8073..8595 Replicon plasmid pS10EC_B
Accession NZ_CP076698
Organism Escherichia coli strain S10EC

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag KQ259_RS24545 Protein ID WP_000220560.1
Coordinates 8314..8595 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag KQ259_RS24540 Protein ID WP_000121743.1
Coordinates 8073..8324 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ259_RS24515 (KQ259_24515) 3675..3956 + 282 WP_021560544.1 hypothetical protein -
KQ259_RS24520 (KQ259_24520) 3981..4958 + 978 WP_021560545.1 hypothetical protein -
KQ259_RS24525 (KQ259_24525) 4955..5311 - 357 WP_021560546.1 DNA distortion polypeptide 3 -
KQ259_RS24530 (KQ259_24530) 5499..5942 - 444 WP_016247723.1 hypothetical protein -
KQ259_RS24535 (KQ259_24535) 5982..6818 - 837 WP_001050931.1 RepB family plasmid replication initiator protein -
KQ259_RS24540 (KQ259_24540) 8073..8324 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
KQ259_RS24545 (KQ259_24545) 8314..8595 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQ259_RS24550 (KQ259_24550) 8741..9064 + 324 WP_156631102.1 hypothetical protein -
KQ259_RS24555 (KQ259_24555) 9109..9354 + 246 WP_000356546.1 hypothetical protein -
KQ259_RS24560 (KQ259_24560) 9344..9559 + 216 WP_001180116.1 hypothetical protein -
KQ259_RS24565 (KQ259_24565) 9652..9981 + 330 WP_000866646.1 hypothetical protein -
KQ259_RS24570 (KQ259_24570) 10024..10203 + 180 WP_000439078.1 hypothetical protein -
KQ259_RS24575 (KQ259_24575) 10273..10422 + 150 WP_000003880.1 hypothetical protein -
KQ259_RS24580 (KQ259_24580) 10435..10707 + 273 WP_000160399.1 hypothetical protein -
KQ259_RS24590 (KQ259_24590) 11038..11583 + 546 WP_000757693.1 DNA distortion polypeptide 1 -
KQ259_RS24595 (KQ259_24595) 11586..12752 + 1167 WP_016247741.1 MobP1 family relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..34316 34316


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T206337 WP_000220560.1 NZ_CP076698:8314-8595 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T206337 NZ_CP102365:c4712935-4711619 [Aeromonas dhakensis]
ATGATGAATGGTTCTGAGCACCATCGGCTGGAACTTCGGCTGGGTAATCAGCTGATCGGCCATCTCGAATATGACTCCAA
CCGGGATTCGTTTCAGCTCGGCTATCTGCCAGAGTGGCAAGCGCGCGGATTCCCACTCTCACCACCACTGGCGTTGGATG
GCTCGGCCAGCAGCGCTCAGATCCGGGCGTATCTCGGCAACTTACTGCCAGAAAATCGCGGGCTGGATCATCTGATTGAG
GTACTCTCCGTTTCGCGCAGCAATCTCTTTGCCCTGATCCACGGTATCGGCCGCGATGTATCCGGGGCTGTCACCTTCAC
CCTACCCGCAGAGCCCGACATTCCCACCCGGTTTCGCCCCATCACACCAGAGGAGTTGATGCTGCGCCTCGATCAACCCG
AGATTTGGCCACTGGAAGTCTGGGATGGCCGCCCCCGACTCTCGGTTGCGGGTGTGCAGGCCAAACTCAACCTGCTGCGA
CTCGAGGGGAGGCTAGGATTTGGCGAAGGTGAACTCTGTTCAACCCACCTCCTCAAGTTCGAGCATCACCCTCATCTGGT
GATCAATGAATTTGTAACCATGCAGCTGGCCGCACAGCTTAGCATGCCGGTGGCGCGGGTCGAACTGCATACTGTGGGTC
AGGGTGAGAAGTCCCACAGAAGCTTGCTGGTGGAACGGTTCGACCGTCGTCTTGATGAGGATGGCATGAGGGTCCGCCGT
CGCCACATGATCGATGCCTGTCAGGGGCTGGGGTTCCCCGTCGCCCGAAAATATGAACGCAACTTCGGTGATGGTCGGGA
CGTGGCCCATATTCGGGAAGGAGTGAGCCTGCCACGGCTGTTCAGCCTTAGCGCTCTCTGCGTCAATCCAGCGCAGGCCA
GACTGGACATGCTGCAATGGCTGCTCTTCAACCTCTGCGTCAACAATCACGATGCCCACGGCAAGAACTACAGCTTCTTC
GTATCAAAAGCAGGGCTGACGCCCACCCCTTGGTACGATCTGGTCAATGTGGGGCTTTACCCCGAGTTCAACCAGCATCT
GGCCATGGCCATAGGCGACGAATTTGCTCCCGAGGCGATCAACGCATGGCAGTTGCTGGAAATGGCCGAGGCATGTGACC
TGCCCGAACGCCTGCTGCAACAGACTTTGCAGAAGATAGCCAGCGACATCCTCCACCATTTGGATGCCGCTATAGCCATG
GTCGAGACAGACCATCCCGCCGAGCTGGATTATCTGGCACGCTATAAAGATGACGTTGAGCGCCGTTGCCACCATTTTCA
GGAGCAGGCGGGGCTGTTGCCCGAACTGCAGCTATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT206337 WP_000121743.1 NZ_CP076698:8073-8324 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT206337 NZ_CP102365:c4713212-4712919 [Aeromonas dhakensis]
ATGACAGATACACCGTTGCCAACCGGCACGAAAGAACTGGATCCCGCCTCGCTGGGACTGGCGATACGGGAGAGACGCAA
AGCAGCCAAGATGACCCAAGAGGTGACGGCCTCACTGTGCGGCATCTCCAAGAAAACCCTGATCAAGATTGAAAAAGGGG
GGGATGTCTACCTCTCGACCCTGCTGCAGGTGATGAAGGCGCTGGGACTGAGGTTGCAACTGGTGCAAGAAGCGGGATCA
CAGGTAATGAGCAGCTACAGCCAACCAGAGGTCGGTGATGATGAATGGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References