Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | shpAB/BrnT-BrnA |
Location | 4997736..4998312 | Replicon | chromosome |
Accession | NZ_CP076697 | ||
Organism | Escherichia coli strain S10EC |
Toxin (Protein)
Gene name | shpA | Uniprot ID | A0A061KXE4 |
Locus tag | KQ259_RS24215 | Protein ID | WP_001295743.1 |
Coordinates | 4997736..4998023 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | shpB | Uniprot ID | A0A066STF6 |
Locus tag | KQ259_RS24220 | Protein ID | WP_000063148.1 |
Coordinates | 4998010..4998312 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KQ259_RS24200 (4993396) | 4993396..4994700 | - | 1305 | WP_000535012.1 | restriction endonuclease subunit S | - |
KQ259_RS24205 (4994690) | 4994690..4996309 | - | 1620 | WP_001029745.1 | class I SAM-dependent DNA methyltransferase | - |
KQ259_RS24210 (4996373) | 4996373..4997539 | - | 1167 | WP_000800831.1 | restriction endonuclease | - |
KQ259_RS24215 (4997736) | 4997736..4998023 | + | 288 | WP_001295743.1 | BrnT family toxin | Toxin |
KQ259_RS24220 (4998010) | 4998010..4998312 | + | 303 | WP_000063148.1 | BrnA antitoxin family protein | Antitoxin |
KQ259_RS24225 (4998346) | 4998346..4999302 | - | 957 | WP_001295745.1 | GTPase | - |
KQ259_RS24230 (4999313) | 4999313..4999516 | - | 204 | WP_000467859.1 | YbdD/YjiX family protein | - |
KQ259_RS24235 (4999566) | 4999566..5001716 | - | 2151 | WP_001295524.1 | pyruvate/proton symporter BtsT | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11156.62 Da Isoelectric Point: 7.4697
>T206336 WP_001295743.1 NZ_CP076697:4997736-4998023 [Escherichia coli]
MPMEFEWDANKAKSNRVKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVHGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERSRYEHG
MPMEFEWDANKAKSNRVKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVHGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERSRYEHG
Download Length: 288 bp
>T206336 NZ_CP102359:c5226028-5225765 [Streptomyces sp. B146]
GTGAGTGAATACCGAACCGTCTTCCGGCCAGAGGCACAGGCCGAGCTCCGGAAGATCCCTCGCGACATGGCCCTACGCAT
CCTGACCAAACTGACCGAACTGGAGAGCGACCCCCTCGGCTATAGCACCACCGCGCTCGTGTCCCAGCCAGAACGCCGTC
GACTGCGGGTCGGCGACTACCGGGTCGTCTACACGATCGACAAGGGGGAGCTCGTGGTGTGGGTCGTCCACGTCGGGCAT
CGCTCCACCGTTTACGAAGCCTGA
GTGAGTGAATACCGAACCGTCTTCCGGCCAGAGGCACAGGCCGAGCTCCGGAAGATCCCTCGCGACATGGCCCTACGCAT
CCTGACCAAACTGACCGAACTGGAGAGCGACCCCCTCGGCTATAGCACCACCGCGCTCGTGTCCCAGCCAGAACGCCGTC
GACTGCGGGTCGGCGACTACCGGGTCGTCTACACGATCGACAAGGGGGAGCTCGTGGTGTGGGTCGTCCACGTCGGGCAT
CGCTCCACCGTTTACGAAGCCTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11592.12 Da Isoelectric Point: 9.4646
>AT206336 WP_000063148.1 NZ_CP076697:4998010-4998312 [Escherichia coli]
MSMVKHKRGTPSTLDVQHEAELKALANKFDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK
MSMVKHKRGTPSTLDVQHEAELKALANKFDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK
Download Length: 303 bp
>AT206336 NZ_CP102359:c5226290-5226021 [Streptomyces sp. B146]
ATGACGCAGCCACTGCCCATAGAGTCCATCCGCGACGTACGTGCGCACCTGGCCGAGGTCGTGGAGCGCGCCGATCGGGA
TGATGTGCCCACCGTGATCACTCGACGGGGCAAGCAGATTGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AATGGGAAGAGCGCGAGATCAATCGGATCATCGACGAACGCATGGCCAACCCGGCACCCGGCATCCCGATCGAGGAGATC
ATGAGGGAGACGCTGGCACGCGGTGAGTGA
ATGACGCAGCCACTGCCCATAGAGTCCATCCGCGACGTACGTGCGCACCTGGCCGAGGTCGTGGAGCGCGCCGATCGGGA
TGATGTGCCCACCGTGATCACTCGACGGGGCAAGCAGATTGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AATGGGAAGAGCGCGAGATCAATCGGATCATCGACGAACGCATGGCCAACCCGGCACCCGGCATCCCGATCGAGGAGATC
ATGAGGGAGACGCTGGCACGCGGTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A061KXE4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A066STF6 |