206327

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 3309131..3310412 Replicon chromosome
Accession NZ_CP076697
Organism Escherichia coli strain S10EC

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1X3JHM4
Locus tag KQ259_RS16200 Protein ID WP_001114681.1
Coordinates 3309519..3310412 (+) Length 298 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID V0YCI1
Locus tag KQ259_RS16195 Protein ID WP_000208383.1
Coordinates 3309131..3309526 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ259_RS16150 (3304625) 3304625..3305110 + 486 WP_000849566.1 antirestriction protein -
KQ259_RS16155 (3305126) 3305126..3305602 + 477 WP_001186726.1 RadC family protein -
KQ259_RS16160 (3305665) 3305665..3305886 + 222 WP_000692329.1 DUF987 domain-containing protein -
KQ259_RS16165 (3305905) 3305905..3306549 + 645 WP_000094916.1 hypothetical protein -
KQ259_RS16170 (3306599) 3306599..3306979 + 381 WP_001285598.1 type IV toxin-antitoxin system YeeU family antitoxin -
KQ259_RS16175 (3307056) 3307056..3307433 + 378 WP_000854689.1 TA system toxin CbtA family protein -
KQ259_RS16180 (3307430) 3307430..3307918 + 489 WP_000761699.1 DUF5983 family protein -
KQ259_RS16185 (3307935) 3307935..3308132 + 198 WP_000839293.1 DUF957 domain-containing protein -
KQ259_RS16190 (3308217) 3308217..3309062 + 846 WP_023281696.1 DUF4942 domain-containing protein -
KQ259_RS16195 (3309131) 3309131..3309526 + 396 WP_000208383.1 DUF6088 family protein Antitoxin
KQ259_RS16200 (3309519) 3309519..3310412 + 894 WP_001114681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KQ259_RS16205 (3310883) 3310883..3311053 + 171 Protein_3195 IS110 family transposase -
KQ259_RS16210 (3311402) 3311402..3312901 + 1500 WP_000174401.1 IS21-like element ISEc10 family transposase -
KQ259_RS16215 (3312898) 3312898..3313653 + 756 Protein_3197 IS21-like element ISEc10 family helper ATPase IstB -
KQ259_RS16220 (3314279) 3314279..3315262 + 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-292)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 34298.40 Da        Isoelectric Point: 5.9850

>T206327 WP_001114681.1 NZ_CP076697:3309519-3310412 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN

Download         Length: 894 bp

>T206327 NZ_CP102358:c946788-946498 [Pseudomonas zeae]
ATGACCGAAGAATTCGCCCGTTTTGACGCCGTCGAGTACCTCAAGACTCCCGAGGATATGGCGGCATATCTGGATGCCTG
TTTTGACGACGATGAAGGCGATGGCGTTCTGATTCGTGCAGCACTCAATGACATCGCCCGAGCTCAAGGCATGACACAAG
TGGCGCGGGATGCAGGTTTGGGTCGCGAAAGTCTTTATAAAGCGCTCAGTAGCACTGGCAATCCCGAATTCGCAACTATC
ATGAAAGTCATGAAGGCTCTGGGTTTGCGATTGCATGCCGTAACACTGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14608.03 Da        Isoelectric Point: 11.3150

>AT206327 WP_000208383.1 NZ_CP076697:3309131-3309526 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA

Download         Length: 396 bp

>AT206327 NZ_CP102358:c947094-946792 [Pseudomonas zeae]
ATGATCGCTTTTGAACGATCCCGCATATTTTCCGAATGGCTCGACTCCTTAAAAGACATCAAAGGGAAAGGCCGAATCAT
CTCCAGGATTAAAACAGCCGAACATGGCAACTTCGGCGATTGCGGCTTCGTCGGTGACACCGTTTATGAAATGCGTGTTC
ATTACGGCCCTGGTTACAGAATGTACTTCACACGTAAAGGCGAAGTGATTTATCTGCTGTTGATCGGGGGCGACAAATCG
ACACAAAAGAGAGATATCAAACGCGCCGTGCAAATGGCTCATAACATCGGAAATGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3JHM4

Antitoxin

Source ID Structure
AlphaFold DB V0YCI1

References