Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2225270..2226101 Replicon chromosome
Accession NZ_CP076697
Organism Escherichia coli strain S10EC

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag KQ259_RS11205 Protein ID WP_000854815.1
Coordinates 2225727..2226101 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag KQ259_RS11200 Protein ID WP_001280918.1
Coordinates 2225270..2225638 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ259_RS11155 (2220359) 2220359..2221105 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
KQ259_RS11160 (2221188) 2221188..2221538 + 351 Protein_2204 hypothetical protein -
KQ259_RS11165 (2221554) 2221554..2221964 + 411 WP_000846703.1 hypothetical protein -
KQ259_RS11170 (2222185) 2222185..2223003 + 819 WP_001542275.1 DUF932 domain-containing protein -
KQ259_RS11175 (2223003) 2223003..2223248 + 246 WP_001164966.1 hypothetical protein -
KQ259_RS11180 (2223342) 2223342..2223815 + 474 WP_001542276.1 antirestriction protein -
KQ259_RS11185 (2223831) 2223831..2224307 + 477 WP_001186200.1 RadC family protein -
KQ259_RS11190 (2224370) 2224370..2224591 + 222 WP_000692345.1 DUF987 domain-containing protein -
KQ259_RS11195 (2224610) 2224610..2225254 + 645 WP_000086752.1 hypothetical protein -
KQ259_RS11200 (2225270) 2225270..2225638 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KQ259_RS11205 (2225727) 2225727..2226101 + 375 WP_000854815.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KQ259_RS11210 (2226098) 2226098..2226292 + 195 WP_000988600.1 DUF5983 family protein -
KQ259_RS11215 (2226338) 2226338..2226418 + 81 Protein_2215 hypothetical protein -
KQ259_RS25440 (2226707) 2226707..2226787 - 81 WP_023441679.1 hypothetical protein -
KQ259_RS25445 (2226766) 2226766..2227089 + 324 WP_225469267.1 EutP/PduV family microcompartment system protein -
KQ259_RS11230 (2227190) 2227190..2227519 - 330 WP_000450409.1 DUF496 family protein -
KQ259_RS11235 (2227691) 2227691..2228749 - 1059 WP_001200889.1 FUSC family protein -
KQ259_RS11240 (2228947) 2228947..2229420 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
KQ259_RS11245 (2229539) 2229539..2230705 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T206323 WP_000854815.1 NZ_CP076697:2225727-2226101 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T206323 NZ_CP102355:c1376427-1376239 [Paracoccus sp. SMMA_5_TC]
ATGGAACGCAACAGCCGGAAGCTGATCAAGATGCTGGAAGCGGACGGCTGGGTCCGGGTCGCGGTCAAGGGCGATCACTG
GCAGTTCAAGCACCCGGAGAAACCCGGCCGCGTGACCGTTCCGCACCCGAACAAGGACATCAAACCCGGCACCGTCATGT
CGATCTATCGACAGGCCGGTTGGCGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT206323 WP_001280918.1 NZ_CP076697:2225270-2225638 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT206323 NZ_CP102355:c1376226-1375819 [Paracoccus sp. SMMA_5_TC]
ATGCGTTACGTCGCTTTCCTGCATACTGACGAAGCCGGCGGCTTCGGCATCAGCTTCCCCGATTTTCCCGGCGCCATCTC
GGACGGCGATACGGTCGAGCAGGCCATCCAGCGCGGCGAGCAGGCGCTGGCTTTCCACGTCCAGGGCATGCGCGAGGACG
GCCTCGACGTCCCTGCCCCCCGCAGCGTTGACGATATCCTGGCCGATCCCGCCCTTGCCGAATGGCGCGAAGGGGCGCAG
ATCGCCCATGTCGCCCTGATCCTGGACCGCGGATCGCCCAAGCGGGTGAACATTTCCCTGGACCCGGGCCTTCTGGACGC
CATCGACGCCGAGGCGGCGCGGCGCGGCATGACGCGCAGCGCGTTCCTGTCCTCGGCGGCACGGGCGGAGATCCATGCGG
CGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References