20631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1737008..1737517 Replicon chromosome
Accession NC_002976
Organism Staphylococcus epidermidis RP62A

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag SERP_RS08475 Protein ID WP_001829980.1
Coordinates 1737008..1737217 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag SERP_RS08480 Protein ID WP_001829893.1
Coordinates 1737224..1737517 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERP_RS08455 1732587..1733942 - 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SERP_RS08460 1733954..1735027 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
SERP_RS08465 1735418..1736629 + 1212 WP_002486299.1 rod shape-determining protein RodA -
SERP_RS08470 1736728..1736865 - 138 WP_001829949.1 hypothetical protein -
SERP_RS08475 1737008..1737217 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
SERP_RS08480 1737224..1737517 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
SERP_RS08485 1737691..1739175 + 1485 WP_002457116.1 cardiolipin synthase -
SERP_RS08490 1739357..1740010 + 654 WP_001829983.1 HD domain-containing protein -
SERP_RS08495 1740116..1740988 - 873 WP_002458703.1 membrane protein insertase YidC -
SERP_RS08500 1741077..1741715 - 639 WP_002505076.1 thiamine phosphate synthase -
SERP_RS08505 1741721..1742509 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T20631 WP_001829980.1 NC_002976:c1737217-1737008 [Staphylococcus epidermidis RP62A]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T20631 NC_002976:c1737217-1737008 [Staphylococcus epidermidis RP62A]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT20631 WP_001829893.1 NC_002976:c1737517-1737224 [Staphylococcus epidermidis RP62A]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT20631 NC_002976:c1737517-1737224 [Staphylococcus epidermidis RP62A]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References