Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 506563..507181 Replicon chromosome
Accession NZ_CP076697
Organism Escherichia coli strain S10EC

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KQ259_RS02400 Protein ID WP_001291435.1
Coordinates 506563..506781 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KQ259_RS02405 Protein ID WP_000344800.1
Coordinates 506807..507181 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ259_RS02365 (501850) 501850..502422 + 573 WP_000779831.1 YbaY family lipoprotein -
KQ259_RS02370 (502453) 502453..502764 - 312 WP_000409908.1 MGMT family protein -
KQ259_RS02380 (503143) 503143..503496 + 354 WP_000878135.1 DUF1428 family protein -
KQ259_RS02385 (503538) 503538..505088 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KQ259_RS02390 (505252) 505252..505722 - 471 WP_000136192.1 YlaC family protein -
KQ259_RS02395 (505838) 505838..506389 - 552 WP_000102539.1 maltose O-acetyltransferase -
KQ259_RS02400 (506563) 506563..506781 - 219 WP_001291435.1 HHA domain-containing protein Toxin
KQ259_RS02405 (506807) 506807..507181 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KQ259_RS02410 (507727) 507727..510876 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
KQ259_RS02415 (510899) 510899..512092 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T206308 WP_001291435.1 NZ_CP076697:c506781-506563 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T206308 NZ_CP102345:c5734227-5733784 [Mycolicibacterium smegmatis]
ATGGCCAAACTTTCCGTCTCCGTCGAAGTTCCATTGCCGCCGGAGCAGGCGTGGGAGTATGCCTCCGACCTGTCCCGGTA
CCACGAGTGGCTCAGCATTCACCGGGCCTGGCGCTCGAAGCTGCCCGAGACCCTGGAGAAGGGCACGGTGATCGAGTCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGGTCAGGTGGACGTTGGTCCACTACAAGCCCCCGCAGGCGCTCACACTCAAC
GGTGACGGCCGCGGCGGGGTCAAGGTCAAGCTGATCGGCAAGATCAAGCCCACCGACAACGGCGCGACGGTGGGCTTCGA
CCTGCACCTCGGCGGCCCAGCCCTGTTCGGGCCCATCGGGATGGTGGTGGCCGCGGCGCTCAAGAGCGACATTCAGGAGT
CGCTCAACCGCTTCAAGCAGCTCTACGCCCCGTCCGCGACCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT206308 WP_000344800.1 NZ_CP076697:c507181-506807 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT206308 NZ_CP102345:c5734425-5734237 [Mycolicibacterium smegmatis]
ATGGGATTCCTGGACAAGGCCAAAGACCTCTTGTCGCAGAACGCCGACAAGGTGGACACCGTCATTGACAAGGCCGGCGA
CATGATCGACGAGAAGACGCAGGGCAAGTACGCCCAGCACGTCGACAAGGCGCAGGACGCCGCGAAGAACGCCATCCACA
AAGACGACCCTCAAGAACCACAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References