Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 129565..130124 | Replicon | plasmid pS103EC_A |
| Accession | NZ_CP076694 | ||
| Organism | Escherichia coli strain S103EC | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | V0SVC8 |
| Locus tag | KQ261_RS26115 | Protein ID | WP_000421272.1 |
| Coordinates | 129565..129840 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0SRR3 |
| Locus tag | KQ261_RS26120 | Protein ID | WP_001387467.1 |
| Coordinates | 129840..130124 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KQ261_RS26080 (125572) | 125572..126354 | - | 783 | WP_216684396.1 | tyrosine-type recombinase/integrase | - |
| KQ261_RS26085 (126475) | 126475..126657 | - | 183 | WP_042065278.1 | hypothetical protein | - |
| KQ261_RS26605 (126724) | 126724..127014 | - | 291 | Protein_159 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KQ261_RS26095 (127001) | 127001..127269 | - | 269 | Protein_160 | type II toxin-antitoxin system ParD family antitoxin | - |
| KQ261_RS26100 (127801) | 127801..128970 | + | 1170 | WP_086732351.1 | hypothetical protein | - |
| KQ261_RS26105 (129003) | 129003..129131 | + | 129 | Protein_162 | IS481 family transposase | - |
| KQ261_RS26110 (129256) | 129256..129459 | - | 204 | Protein_163 | hypothetical protein | - |
| KQ261_RS26115 (129565) | 129565..129840 | - | 276 | WP_000421272.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KQ261_RS26120 (129840) | 129840..130124 | - | 285 | WP_001387467.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| KQ261_RS26125 (130729) | 130729..131481 | + | 753 | WP_001403368.1 | IclR family transcriptional regulator | - |
| KQ261_RS26130 (131527) | 131527..132492 | - | 966 | WP_001022265.1 | 2-keto-3-deoxygluconate transporter | - |
| KQ261_RS26135 (132525) | 132525..132905 | - | 381 | WP_000710783.1 | Rid family detoxifying hydrolase | - |
| KQ261_RS26140 (132930) | 132930..133820 | - | 891 | WP_001077068.1 | dihydrodipicolinate synthase family protein | - |
| KQ261_RS26145 (134053) | 134053..134247 | - | 195 | WP_000796505.1 | hypothetical protein | - |
| KQ261_RS26150 (134221) | 134221..134661 | + | 441 | Protein_171 | zinc-binding dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..146805 | 146805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10749.45 Da Isoelectric Point: 10.0871
>T206305 WP_000421272.1 NZ_CP076694:c129840-129565 [Escherichia coli]
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T206305 NZ_CP102345:1377361-1377750 [Mycolicibacterium smegmatis]
ATGGTTATCGACACTTCTGCCCTCGTTGCCATCTTGACCGACGAACCCGACGCCGAGTTGTTGGAGGGGGCGGTGGCTGA
CGATCCTGTTCGGACTATGTCCACCGCGTCGTATCTGGAGACAGCGATCGTGATCGAAAGTCGCTTCGGCGAGCCAGGTG
GTCGCGAACTCGATCTGTGGTTGCATCGCGCATCAGTGGCACTGGTCGCTGTGGATGCCGATCAGGCCGACGCCGCCCGG
TTGGCTTACCGGAGATACGGCAAGGGGCGCCATCGTGCAGGCCTGAATTACGGCGACTGTTTTTCCTATGCGCTCGCCAA
GGTCAGCGGTCAGCCTTTGTTGTTCAAGGGCGAGGCTTTTCGGCTCACCGACGTCGCTGCGGTCCACTGA
ATGGTTATCGACACTTCTGCCCTCGTTGCCATCTTGACCGACGAACCCGACGCCGAGTTGTTGGAGGGGGCGGTGGCTGA
CGATCCTGTTCGGACTATGTCCACCGCGTCGTATCTGGAGACAGCGATCGTGATCGAAAGTCGCTTCGGCGAGCCAGGTG
GTCGCGAACTCGATCTGTGGTTGCATCGCGCATCAGTGGCACTGGTCGCTGTGGATGCCGATCAGGCCGACGCCGCCCGG
TTGGCTTACCGGAGATACGGCAAGGGGCGCCATCGTGCAGGCCTGAATTACGGCGACTGTTTTTCCTATGCGCTCGCCAA
GGTCAGCGGTCAGCCTTTGTTGTTCAAGGGCGAGGCTTTTCGGCTCACCGACGTCGCTGCGGTCCACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10460.87 Da Isoelectric Point: 5.6558
>AT206305 WP_001387467.1 NZ_CP076694:c130124-129840 [Escherichia coli]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
Download Length: 285 bp
>AT206305 NZ_CP102345:1377107-1377361 [Mycolicibacterium smegmatis]
ATGGCTCTAAGCATCAAACACCCGGAAGCCGACCGGCTGGCCAGAGAGCTAGCGGCACGTACGGGGGAGACACTGACCGA
GGCGGTGGTGATGGCACTGCGGGAGCGACTGGCGCGCACTGTCGGCCGCACTCAGGTCGTTCCGCTTCGTGAGGAACTCG
CCGCGATCCGTCGTCGCTGCGCAGCCCTACCGGTGTTGGACGACCGGACAGCCGAATCGATCCTGGGCTACGACGACCGC
GGTCTGCCGTCCTGA
ATGGCTCTAAGCATCAAACACCCGGAAGCCGACCGGCTGGCCAGAGAGCTAGCGGCACGTACGGGGGAGACACTGACCGA
GGCGGTGGTGATGGCACTGCGGGAGCGACTGGCGCGCACTGTCGGCCGCACTCAGGTCGTTCCGCTTCGTGAGGAACTCG
CCGCGATCCGTCGTCGCTGCGCAGCCCTACCGGTGTTGGACGACCGGACAGCCGAATCGATCCTGGGCTACGACGACCGC
GGTCTGCCGTCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0SVC8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y880 |