Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1725803..1726332 Replicon chromosome
Accession NC_002976
Organism Staphylococcus epidermidis RP62A

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag SERP_RS08415 Protein ID WP_001829891.1
Coordinates 1725803..1726165 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag SERP_RS08420 Protein ID WP_001829931.1
Coordinates 1726162..1726332 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERP_RS08395 1722805..1723575 - 771 WP_002440602.1 RNA polymerase sigma factor SigB -
SERP_RS08400 1723550..1724029 - 480 WP_001829903.1 anti-sigma B factor RsbW -
SERP_RS08405 1724031..1724357 - 327 WP_001829952.1 anti-sigma factor antagonist -
SERP_RS08410 1724457..1725458 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
SERP_RS08415 1725803..1726165 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SERP_RS08420 1726162..1726332 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
SERP_RS08425 1726419..1727567 - 1149 WP_002457107.1 alanine racemase -
SERP_RS08430 1727634..1727987 - 354 WP_002457108.1 holo-ACP synthase -
SERP_RS08435 1728035..1728544 - 510 WP_002457109.1 PH domain-containing protein -
SERP_RS08440 1728531..1730036 - 1506 WP_002457110.1 PH domain-containing protein -
SERP_RS08445 1730029..1730508 - 480 WP_010959254.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T20630 WP_001829891.1 NC_002976:c1726165-1725803 [Staphylococcus epidermidis RP62A]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T20630 NC_002976:c1726165-1725803 [Staphylococcus epidermidis RP62A]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT20630 WP_001829931.1 NC_002976:c1726332-1726162 [Staphylococcus epidermidis RP62A]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT20630 NC_002976:c1726332-1726162 [Staphylococcus epidermidis RP62A]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References