Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4946281..4946876 Replicon chromosome
Accession NZ_CP076693
Organism Escherichia coli strain S103EC

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag KQ261_RS24155 Protein ID WP_000239579.1
Coordinates 4946526..4946876 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag KQ261_RS24150 Protein ID WP_001223208.1
Coordinates 4946281..4946532 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ261_RS24140 (4941946) 4941946..4945725 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
KQ261_RS24145 (4945728) 4945728..4946069 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
KQ261_RS24150 (4946281) 4946281..4946532 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KQ261_RS24155 (4946526) 4946526..4946876 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
KQ261_RS24160 (4946956) 4946956..4947486 - 531 WP_000055075.1 inorganic diphosphatase -
KQ261_RS24165 (4947796) 4947796..4948752 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KQ261_RS24170 (4948892) 4948892..4950394 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
KQ261_RS24175 (4950408) 4950408..4951430 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T206293 WP_000239579.1 NZ_CP076693:4946526-4946876 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T206293 NZ_CP102342:c5734226-5733783 [Mycolicibacterium smegmatis]
ATGGCCAAACTTTCCGTCTCCGTCGAAGTTCCATTGCCGCCGGAGCAGGCGTGGGAGTATGCCTCCGACCTGTCCCGGTA
CCACGAGTGGCTCAGCATTCACCGGGCCTGGCGCTCGAAGCTGCCCGAGACCCTGGAGAAGGGCACGGTGATCGAGTCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGGTCAGGTGGACGTTGGTCCACTACAAGCCCCCGCAGGCGCTCACACTCAAC
GGTGACGGCCGCGGCGGGGTCAAGGTCAAGCTGATCGGCAAGATCAAGCCCACCGACAACGGCGCGACGGTGGGCTTCGA
CCTGCACCTCGGCGGCCCAGCCCTGTTCGGGCCCATCGGGATGGTGGTGGCCGCGGCGCTCAAGAGCGACATTCAGGAGT
CGCTCAACCGCTTCAAGCAGCTCTACGCCCCGTCCGCGACCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT206293 WP_001223208.1 NZ_CP076693:4946281-4946532 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT206293 NZ_CP102342:c5734424-5734236 [Mycolicibacterium smegmatis]
ATGGGATTCCTGGACAAGGCCAAAGACCTCTTGTCGCAGAACGCCGACAAGGTGGACACCGTCATTGACAAGGCCGGCGA
CATGATCGACGAGAAGACGCAGGGCAAGTACGCCCAGCACGTCGACAAGGCGCAGGACGCCGCGAAGAACGCCATCCACA
AAGACGACCCTCAAGAACCACAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References