Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4807801..4808636 Replicon chromosome
Accession NZ_CP076693
Organism Escherichia coli strain S103EC

Toxin (Protein)


Gene name yeeV Uniprot ID S1PMM7
Locus tag KQ261_RS23415 Protein ID WP_000854720.1
Coordinates 4807801..4808178 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P8X0
Locus tag KQ261_RS23420 Protein ID WP_001539669.1
Coordinates 4808268..4808636 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ261_RS23385 (4803761) 4803761..4805026 - 1266 WP_001218773.1 integrase arm-type DNA-binding domain-containing protein -
KQ261_RS23390 (4805490) 4805490..4805816 - 327 WP_000779482.1 type II toxin-antitoxin system RelE/ParE family toxin -
KQ261_RS23395 (4805813) 4805813..4806076 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
KQ261_RS23400 (4806148) 4806148..4807014 - 867 WP_001290180.1 DUF4942 domain-containing protein -
KQ261_RS23405 (4807107) 4807107..4807304 - 198 WP_000839238.1 DUF957 domain-containing protein -
KQ261_RS23410 (4807316) 4807316..4807804 - 489 WP_000777672.1 DUF5983 family protein -
KQ261_RS23415 (4807801) 4807801..4808178 - 378 WP_000854720.1 TA system toxin CbtA family protein Toxin
KQ261_RS23420 (4808268) 4808268..4808636 - 369 WP_001539669.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KQ261_RS23425 (4808716) 4808716..4808937 - 222 WP_000692349.1 DUF987 domain-containing protein -
KQ261_RS23430 (4809024) 4809024..4809500 - 477 WP_001186788.1 RadC family protein -
KQ261_RS23435 (4809516) 4809516..4810001 - 486 WP_016237304.1 antirestriction protein -
KQ261_RS23440 (4810056) 4810056..4810874 - 819 WP_001234642.1 DUF932 domain-containing protein -
KQ261_RS23445 (4810974) 4810974..4811147 - 174 WP_000088744.1 DUF905 family protein -
KQ261_RS26520 (4811267) 4811267..4811509 - 243 WP_230592266.1 DNA polymerase III subunit gamma/tau -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4793506..4831149 37643
- flank IS/Tn - - 4811713..4812216 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14089.02 Da        Isoelectric Point: 7.9087

>T206292 WP_000854720.1 NZ_CP076693:c4808178-4807801 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T206292 NZ_CP102342:4541441-4541770 [Mycolicibacterium smegmatis]
GTGCGGCGCGGCGATATCTACACCGCGGCGGCGCGAGGTGCGTACACCGGCAAGCCTCGGCCGGTCCTCATCATCCAGGA
CGACCGATTCGATGCCACCGCGTCGGTCACCGTCGTGCCGTTTACGACAAGCGACACCGACGCACCGCTTCTGCGAATTC
GAATCGAGCCAACGCCAGCCACCGGACTCTCCACGGTCAGCTCGTTGATGATCGACAAGGTGACCACAGTTCCCCGCTCC
AGCTTGACGCACCGTGTCGGCCGACTGGCGGAGACAGACATGGTCAGGACCGACCGCGCACTCCTGGTTTTTCTGGGAAT
CGCCGGGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13614.39 Da        Isoelectric Point: 5.9550

>AT206292 WP_001539669.1 NZ_CP076693:c4808636-4808268 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSN
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT206292 NZ_CP102342:4541229-4541438 [Mycolicibacterium smegmatis]
ATGACTCCCGCGCGTGACCGAGTACGCCGACATCGCGAGCGGCTGCGGCGACAAGGTCTGCGGCCGGTGCAGATCTGGGT
CCCCGACGTGAATGCACCCGAATTTCGCCGGGAGGCGCACCGGCAGTCTGAGTTGGTCGCCGCCGGCGAGCATGAGGCCG
AAGATCAAGCTTTCGTCGACGCGATCTCCGTCGACTGGGACGACGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FW05

Antitoxin

Source ID Structure
AlphaFold DB A0A829FYK7

References