Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4734650..4735485 Replicon chromosome
Accession NZ_CP076693
Organism Escherichia coli strain S103EC

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7U9IW37
Locus tag KQ261_RS23015 Protein ID WP_023356554.1
Coordinates 4734650..4735027 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9IW59
Locus tag KQ261_RS23020 Protein ID WP_001360327.1
Coordinates 4735117..4735485 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ261_RS22995 (4731017) 4731017..4732555 - 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -
KQ261_RS26475 (4732815) 4732815..4732974 - 160 Protein_4511 integrase -
KQ261_RS23000 (4733304) 4733304..4734146 - 843 WP_022645115.1 DUF4942 domain-containing protein -
KQ261_RS23005 (4734231) 4734231..4734425 - 195 WP_024181941.1 DUF957 domain-containing protein -
KQ261_RS23010 (4734504) 4734504..4734653 - 150 Protein_4514 DUF5983 family protein -
KQ261_RS23015 (4734650) 4734650..4735027 - 378 WP_023356554.1 TA system toxin CbtA family protein Toxin
KQ261_RS23020 (4735117) 4735117..4735485 - 369 WP_001360327.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KQ261_RS23025 (4735648) 4735648..4735869 - 222 WP_023356553.1 DUF987 domain-containing protein -
KQ261_RS23030 (4735932) 4735932..4736408 - 477 WP_023356600.1 RadC family protein -
KQ261_RS23035 (4736424) 4736424..4736903 - 480 WP_000706978.1 antirestriction protein -
KQ261_RS23040 (4737169) 4737169..4737987 - 819 WP_001175165.1 DUF932 domain-containing protein -
KQ261_RS23045 (4738077) 4738077..4738310 - 234 WP_001278293.1 DUF905 family protein -
KQ261_RS23050 (4738316) 4738316..4738993 - 678 WP_001097302.1 hypothetical protein -
KQ261_RS23055 (4739141) 4739141..4739821 - 681 WP_023356552.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4707613..4775830 68217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14052.01 Da        Isoelectric Point: 7.8045

>T206291 WP_023356554.1 NZ_CP076693:c4735027-4734650 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIEQHIEAGIALCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T206291 NZ_CP102342:3517540-3518118 [Mycolicibacterium smegmatis]
GTGAAACGACTCGATCTCGTCGTTGGTCCCAACGGCGCGGGCAAGAGCACTTTCGTCGAACTCACATTGGCCCCGCTGCT
GACGGGCAGTGCGTTCGTCAACGCCGACGAGATCGCCAAGCGTCGCTGGCCGCACGCCCCGGCCGAGCACTCCTACGAGG
CCGCACGCATCGCCTCCGACACCCGACTCAAGCTGATCGAACTCGGTGAATCGTTCATCGCCGAAACGGTGTTCTCACAT
CCCTCGAAACTTCAGCTCATCGACACCGCGCAGGCGGCTGGATACACCGTGGTAATGCACGTGGTGATGATCCCCGAGGA
TCTCGCCGTCCTACGCGTGCAGCACCGGGTACGAGCCGGTGGTCACCATGTGCCCGAGGAGAAGATCCGCGAACGGCACC
AACGACTCTGGCCCCTCGTCGCGCTGGCGGCCGCCCGCGCCGACATCTCGACGTTCTATGACAACAGCGCCGTCAGGGGT
CCGCGCATCGTTGCCCAACTCGCCGGCGGATTTGCTGTGGGCCGGCCCGCCTGGCCAATGTGGGCACCCCAGGTGCTCAC
CTCGCGGTGGCCCGAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.34 Da        Isoelectric Point: 5.9598

>AT206291 WP_001360327.1 NZ_CP076693:c4735485-4735117 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT206291 NZ_CP102342:3517122-3517514 [Mycolicibacterium smegmatis]
ATGACTGAGACCGCAGATCGGGTCACTCGCTTCGCCGCAGACCTGGTGGAGAGCGCCGCGGCCGAAGGCGCACGTCAGAG
TAGGTCGGCCAAGCAGCAACTCGACCATTGGGCACGAGTGGGGCGGGCGGTGTCGAGCCAACACACCGCCGCCCGCCGCC
GGGTGGAAGCCGCGCTCGCCGGGGACCTGGCGCTACGCGATCTGACTCCTGAGGAAGGCGTCGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAGAATCTGGCGCACACCGATTACGGCCAGGTCCTCGCCGGGCGCGGCGTGACCACCGTCGCTCT
CGACGACGACGGTGCCATCGTGCGGTACCAACCGGACGGCACCACGACCGTGCTGGCTCCTGCGCAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9IW37

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9IW59

References