Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4723204..4723701 Replicon chromosome
Accession NZ_CP076693
Organism Escherichia coli strain S103EC

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag KQ261_RS22970 Protein ID WP_001173343.1
Coordinates 4723528..4723701 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag KQ261_RS22965 Protein ID WP_001312331.1
Coordinates 4723204..4723500 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ261_RS22955 (4718561) 4718561..4722490 + 3930 WP_001080129.1 autotransporter outer membrane beta-barrel domain-containing protein -
KQ261_RS22960 (4722704) 4722704..4722976 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
KQ261_RS22965 (4723204) 4723204..4723500 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
KQ261_RS22970 (4723528) 4723528..4723701 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
KQ261_RS22975 (4723820) 4723820..4725337 - 1518 WP_000003806.1 lysine--tRNA ligase -
KQ261_RS22980 (4725574) 4725574..4727031 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4707613..4775830 68217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T206290 WP_001173343.1 NZ_CP076693:4723528-4723701 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T206290 NZ_CP102342:1377361-1377750 [Mycolicibacterium smegmatis]
ATGGTTATCGACACTTCTGCCCTCGTTGCCATCTTGACCGACGAACCCGACGCCGAGTTGTTGGAGGGGGCGGTGGCTGA
CGATCCTGTTCGGACTATGTCCACCGCGTCGTATCTGGAGACAGCGATCGTGATCGAAAGTCGCTTCGGCGAGCCAGGTG
GTCGCGAACTCGATCTGTGGTTGCATCGCGCATCAGTGGCACTGGTCGCTGTGGATGCCGATCAGGCCGACGCCGCCCGG
TTGGCTTACCGGAGATACGGCAAGGGGCGCCATCGTGCAGGCCTGAATTACGGCGACTGTTTTTCCTATGCGCTCGCCAA
GGTCAGCGGTCAGCCTTTGTTGTTCAAGGGCGAGGCTTTTCGGCTCACCGACGTCGCTGCGGTCCACTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT206290 WP_001312331.1 NZ_CP076693:4723204-4723500 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp

>AT206290 NZ_CP102342:1377107-1377361 [Mycolicibacterium smegmatis]
ATGGCTCTAAGCATCAAACACCCGGAAGCCGACCGGCTGGCCAGAGAGCTAGCGGCACGTACGGGGGAGACACTGACCGA
GGCGGTGGTGATGGCACTGCGGGAGCGACTGGCGCGCACTGTCGGCCGCACTCAGGTCGTTCCGCTTCGTGAGGAACTCG
CCGCGATCCGTCGTCGCTGCGCAGCCCTACCGGTGTTGGACGACCGGACAGCCGAATCGATCCTGGGCTACGACGACCGC
GGTCTGCCGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References