Detailed information of TA system TA206285

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3379051..3379885
• Replicon: chromosome
• Accession: NZ_CP076693
• Organism: Escherichia coli strain S103EC

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: S1PLF5
• Locus tag: KQ261_RS16620
• Protein ID: WP_000854690.1
• Coordinates: 3379508..3379885 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: S1P7N8
• Locus tag: KQ261_RS16615
• Protein ID: WP_001305076.1
• Coordinates: 3379051..3379419 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ261_RS16575 (3374133)	3374133..3375260	+	1128	Protein_3263	hypothetical protein	-
KQ261_RS16580 (3375336)	3375336..3375791	+	456	WP_000581502.1	IrmA family protein	-
KQ261_RS16585 (3375870)	3375870..3376103	+	234	WP_000902034.1	DUF905 family protein	-
KQ261_RS16590 (3376204)	3376204..3377022	+	819	WP_001234620.1	DUF932 domain-containing protein	-
KQ261_RS16595 (3377077)	3377077..3377562	+	486	WP_000849565.1	antirestriction protein	-
KQ261_RS16600 (3377578)	3377578..3378054	+	477	WP_001186726.1	RadC family protein	-
KQ261_RS16605 (3378117)	3378117..3378338	+	222	WP_000692329.1	DUF987 domain-containing protein	-
KQ261_RS16610 (3378357)	3378357..3379001	+	645	WP_000094916.1	hypothetical protein	-
KQ261_RS16615 (3379051)	3379051..3379419	+	369	WP_001305076.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KQ261_RS16620 (3379508)	3379508..3379885	+	378	WP_000854690.1	TA system toxin CbtA family protein	Toxin
KQ261_RS16625 (3379882)	3379882..3380370	+	489	WP_000761699.1	DUF5983 family protein	-
KQ261_RS16630 (3380387)	3380387..3380584	+	198	WP_000839293.1	DUF957 domain-containing protein	-
KQ261_RS16635 (3380669)	3380669..3381514	+	846	WP_001529401.1	DUF4942 domain-containing protein	-
KQ261_RS16640 (3381583)	3381583..3381978	+	396	WP_000208384.1	DUF6088 family protein	-
KQ261_RS16645 (3381971)	3381971..3382904	+	934	Protein_3277	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
KQ261_RS16650 (3383321)	3383321..3383491	+	171	Protein_3278	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / kpsT / kpsM	3377578..3398555	20977
	-	flank	IS/Tn	-	-	3383336..3383491	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14057.04 Da
• Isoelectric Point: 9.1510

>T206285 WP_000854690.1 NZ_CP076693:3379508-3379885 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T206285 NZ_CP102330:c1815790-1814894 [Burkholderia cepacia]
ATGAGTGTCATCGACAAACGCGAGCGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTACCGTGAGGCCGGCGCGCAGCATGGGGGCCGTGCGCTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTCAGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GACGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCGGCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGTGGTCTCGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATTTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGACACGCGC
GAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGACGCACGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTTCGCGGTCGCACGGCCGTGGCCGTCGGT
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCCGGTCATGCCGGTTATGTCGAGGCGCCGGCCGTCTATTCCGCACTGATCGACACGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13560.39 Da
• Isoelectric Point: 4.7830

>AT206285 WP_001305076.1 NZ_CP076693:3379051-3379419 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Nucleotide

• Length: 369 bp

>AT206285 NZ_CP102330:c1814897-1814040 [Burkholderia cepacia]
ATGAACGAACCGCTGCAACGACCCGAACCCGAAAACGACAAGGCCGAAGCCAGCTACGTGGTGCCCGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGTGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
GAGCCTGCGCGACGCCACCGGCTTCACGACGCACATCGTGATCCGTGATGGCCGAGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTCAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCGCTCGCTGTATCCGGAAGGCACGCTGAACCGGATGACGAACGCGAC
ACCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGTCCGGAAATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTCATGAAAGCATTAGGACTCCGATGA

Structures

Toxin

• AlphaFold DB: S1PLF5

Antitoxin

• AlphaFold DB: S1P7N8