Detailed information of TA system TA020625

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2252940..2253525
• Replicon: chromosome
• Accession: NC_002967
• Organism: Treponema denticola ATCC 35405

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q73KK5
• Locus tag: TDE_RS10465
• Protein ID: WP_002680062.1
• Coordinates: 2252940..2253197 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q73KK4
• Locus tag: TDE_RS10470
• Protein ID: WP_002668012.1
• Coordinates: 2253190..2253525 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TDE_RS10450	2249484..2250791	-	1308	WP_002680054.1	right-handed parallel beta-helix repeat-containing protein	-
TDE_RS10455	2250807..2251406	-	600	WP_002675657.1	hypothetical protein	-
TDE_RS10460	2251572..2252771	-	1200	WP_002680060.1	galactokinase	-
TDE_RS10465	2252940..2253197	+	258	WP_002680062.1	type II toxin-antitoxin system HicA family toxin	Toxin
TDE_RS10470	2253190..2253525	+	336	WP_002668012.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
TDE_RS10475	2253531..2255225	-	1695	WP_002680065.1	galactoside ABC transporter permease	-
TDE_RS10480	2255250..2256743	-	1494	WP_002680067.1	sugar ABC transporter ATP-binding protein	-
TDE_RS10485	2256854..2258065	-	1212	WP_002674469.1	substrate-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-82)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9590.87 Da
• Isoelectric Point: 10.2014

>T20625 WP_002680062.1 NC_002967:2252940-2253197 [Treponema denticola ATCC 35405]
VNTKNKKTLENIYKRPVPADIFWTDIESLFISLGAEISEGAGSRIRVKLNNTRAVFHRPHPEKITDKGAVNSVRRFLENA
GVEND

Nucleotide

• Length: 258 bp

>T20625 NC_002967:2252940-2253197 [Treponema denticola ATCC 35405]
GTGAATACAAAGAATAAAAAAACACTTGAGAACATATATAAACGACCTGTTCCTGCAGATATTTTTTGGACCGATATCGA
AAGCCTATTTATTTCATTAGGTGCGGAAATTTCTGAGGGAGCAGGCTCTCGAATAAGGGTAAAATTGAATAATACACGGG
CTGTTTTTCATAGACCGCATCCTGAAAAAATTACAGATAAGGGAGCTGTTAATTCGGTTAGACGATTTTTAGAAAATGCA
GGAGTAGAAAATGATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12628.35 Da
• Isoelectric Point: 4.9348

>AT20625 WP_002668012.1 NC_002967:2253190-2253525 [Treponema denticola ATCC 35405]
MIEYKGYIGKIEYDPEAKILHGDVINTRDVITFQGTSVAEIEKAFIDSVDDYINWCREENIEPEKPYSGKFNIRISPELH
KKIAINAKSLNLSLNTFVEKALQHELASTGI

Nucleotide

• Length: 336 bp

>AT20625 NC_002967:2253190-2253525 [Treponema denticola ATCC 35405]
ATGATTGAATATAAGGGATATATCGGAAAAATAGAATACGATCCGGAAGCAAAAATTTTACATGGAGATGTCATAAATAC
ACGTGATGTTATTACATTCCAGGGTACAAGCGTAGCAGAAATAGAAAAAGCCTTTATTGACTCTGTCGATGATTACATCA
ACTGGTGCCGAGAAGAAAATATAGAACCCGAAAAACCATATTCGGGAAAATTCAATATACGCATATCACCGGAGCTTCAT
AAAAAAATAGCAATCAACGCAAAAAGCTTAAATCTTTCTTTAAATACTTTTGTTGAAAAAGCATTACAACATGAATTAGC
ATCTACCGGAATATAA

Structures

Toxin

• AlphaFold DB: Q73KK5

Antitoxin

• AlphaFold DB: Q73KK4