Detailed information of TA system TA206235

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 360449..362138
• Replicon: chromosome
• Accession: NZ_CP076689
• Organism: Escherichia coli strain S21EC

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: KQ260_RS01820
• Protein ID: WP_000365807.1
• Coordinates: 361218..362138 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: KQ260_RS01815
• Protein ID: WP_001295795.1
• Coordinates: 360449..361231 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ260_RS01810 (357067)	357067..360165	-	3099	WP_000673070.1	type I restriction endonuclease	-
KQ260_RS01815 (360449)	360449..361231	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
KQ260_RS01820 (361218)	361218..362138	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KQ260_RS25570 (362303)	362303..363079	-	777	WP_000171155.1	site-specific integrase	-
KQ260_RS25575 (363287)	363287..363622	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
KQ260_RS01830 (363849)	363849..364007	-	159	Protein_357	integrase	-
KQ260_RS01835 (364056)	364056..364241	+	186	WP_000146240.1	hypothetical protein	-
KQ260_RS01840 (364456)	364456..365070	+	615	WP_001019923.1	YagU family protein	-
KQ260_RS01845 (365141)	365141..365307	+	167	Protein_360	tail fiber assembly protein	-
KQ260_RS01850 (365319)	365319..365648	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
KQ260_RS01855 (365955)	365955..366665	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	354199..402355	48156

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T206235 WP_000365807.1 NZ_CP076689:361218-362138 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

>T206235 NZ_CP102244:2930399-2930506 [Escherichia coli O7:H15]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT206235 WP_001295795.1 NZ_CP076689:360449-361231 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT206235 NZ_CP102244:c2930349-2930286 [Escherichia coli O7:H15]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A061KTE0