Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 49181..49706 | Replicon | plasmid pS22EC_A |
Accession | NZ_CP076688 | ||
Organism | Escherichia coli strain S22EC |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | S1PFV8 |
Locus tag | KQ258_RS24975 | Protein ID | WP_001159871.1 |
Coordinates | 49401..49706 (+) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | S1PPD8 |
Locus tag | KQ258_RS24970 | Protein ID | WP_000813634.1 |
Coordinates | 49181..49399 (+) | Length | 73 a.a. |
Genomic Context
Location: 49181..49399 (219 bp)
Type: Antitoxin
Protein ID: WP_000813634.1
Type: Antitoxin
Protein ID: WP_000813634.1
Location: 49401..49706 (306 bp)
Type: Toxin
Protein ID: WP_001159871.1
Type: Toxin
Protein ID: WP_001159871.1
Location: 49707..50516 (810 bp)
Type: Others
Protein ID: WP_000016979.1
Type: Others
Protein ID: WP_000016979.1
Location: 51796..52767 (972 bp)
Type: Others
Protein ID: WP_001103694.1
Type: Others
Protein ID: WP_001103694.1
Location: 52772..53164 (393 bp)
Type: Others
Protein ID: WP_000340835.1
Type: Others
Protein ID: WP_000340835.1
Location: 46218..46859 (642 bp)
Type: Others
Protein ID: WP_000990667.1
Type: Others
Protein ID: WP_000990667.1
Location: 50654..50929 (276 bp)
Type: Others
Protein ID: WP_000239529.1
Type: Others
Protein ID: WP_000239529.1
Location: 50923..51567 (645 bp)
Type: Others
Protein ID: WP_000633911.1
Type: Others
Protein ID: WP_000633911.1
Location: 53169..54439 (1271 bp)
Type: Others
Protein ID: Protein_56
Type: Others
Protein ID: Protein_56
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KQ258_RS24965 (46218) | 46218..46859 | - | 642 | WP_000990667.1 | hypothetical protein | - |
KQ258_RS24970 (49181) | 49181..49399 | + | 219 | WP_000813634.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
KQ258_RS24975 (49401) | 49401..49706 | + | 306 | WP_001159871.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
KQ258_RS24980 (49707) | 49707..50516 | + | 810 | WP_000016979.1 | site-specific integrase | - |
KQ258_RS24985 (50654) | 50654..50929 | - | 276 | WP_000239529.1 | hypothetical protein | - |
KQ258_RS24990 (50923) | 50923..51567 | - | 645 | WP_000633911.1 | AAA family ATPase | - |
KQ258_RS24995 (51796) | 51796..52767 | + | 972 | WP_001103694.1 | plasmid segregation protein ParM | - |
KQ258_RS25000 (52772) | 52772..53164 | + | 393 | WP_000340835.1 | plasmid partitioning/stability family protein | - |
KQ258_RS25005 (53169) | 53169..54439 | - | 1271 | Protein_56 | translesion error-prone DNA polymerase V subunit UmuC | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | senB | 1..116936 | 116936 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11692.49 Da Isoelectric Point: 6.4674
>T206233 WP_001159871.1 NZ_CP076688:49401-49706 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T206233 NZ_CP102244:c2676322-2676146 [Escherichia coli O7:H15]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8372.34 Da Isoelectric Point: 4.7405
>AT206233 WP_000813634.1 NZ_CP076688:49181-49399 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT206233 NZ_CP102244:c2676100-2675684 [Escherichia coli O7:H15]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCCTTACTCACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCCTTACTCACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTAA