Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 49181..49706 Replicon plasmid pS22EC_A
Accession NZ_CP076688
Organism Escherichia coli strain S22EC

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag KQ258_RS24975 Protein ID WP_001159871.1
Coordinates 49401..49706 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag KQ258_RS24970 Protein ID WP_000813634.1
Coordinates 49181..49399 (+) Length 73 a.a.

Genomic Context


KQ258_RS24970KQ258_RS24975KQ258_RS24980KQ258_RS24995KQ258_RS25000KQ258_RS24965KQ258_RS24985KQ258_RS24990KQ258_RS25005
Location: 49181..49399 (219 bp)
Type: Antitoxin
Protein ID: WP_000813634.1
Location: 49401..49706 (306 bp)
Type: Toxin
Protein ID: WP_001159871.1
Location: 49707..50516 (810 bp)
Type: Others
Protein ID: WP_000016979.1
Location: 51796..52767 (972 bp)
Type: Others
Protein ID: WP_001103694.1
Location: 52772..53164 (393 bp)
Type: Others
Protein ID: WP_000340835.1
Location: 46218..46859 (642 bp)
Type: Others
Protein ID: WP_000990667.1
Location: 50654..50929 (276 bp)
Type: Others
Protein ID: WP_000239529.1
Location: 50923..51567 (645 bp)
Type: Others
Protein ID: WP_000633911.1
Location: 53169..54439 (1271 bp)
Type: Others
Protein ID: Protein_56
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KQ258_RS24965 (46218)46218..46859-642WP_000990667.1hypothetical protein-
KQ258_RS24970 (49181)49181..49399+219WP_000813634.1type II toxin-antitoxin system antitoxin CcdAAntitoxin
KQ258_RS24975 (49401)49401..49706+306WP_001159871.1type II toxin-antitoxin system toxin CcdBToxin
KQ258_RS24980 (49707)49707..50516+810WP_000016979.1site-specific integrase-
KQ258_RS24985 (50654)50654..50929-276WP_000239529.1hypothetical protein-
KQ258_RS24990 (50923)50923..51567-645WP_000633911.1AAA family ATPase-
KQ258_RS24995 (51796)51796..52767+972WP_001103694.1plasmid segregation protein ParM-
KQ258_RS25000 (52772)52772..53164+393WP_000340835.1plasmid partitioning/stability family protein-
KQ258_RS25005 (53169)53169..54439-1271Protein_56translesion error-prone DNA polymerase V subunit UmuC-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmid-senB1..116936116936


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-100)

Antitoxin

(2-72)


Sequences


Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T206233 WP_001159871.1 NZ_CP076688:49401-49706 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T206233 NZ_CP102244:c2676322-2676146 [Escherichia coli O7:H15]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.34 Da        Isoelectric Point: 4.7405

>AT206233 WP_000813634.1 NZ_CP076688:49181-49399 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT206233 NZ_CP102244:c2676100-2675684 [Escherichia coli O7:H15]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCCTTACTCACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A829CCE8


Antitoxin

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Source
ID
Structure
PDB3TCJ
PDB2H3A
PDB2ADN
PDB2ADL
PDB3HPW
PDB2H3C
PDB3G7Z
AlphaFold DBA0A829CQY2

References