Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4762594..4763429 | Replicon | chromosome |
| Accession | NZ_CP076687 | ||
| Organism | Escherichia coli strain S22EC | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PMM7 |
| Locus tag | KQ258_RS23175 | Protein ID | WP_000854720.1 |
| Coordinates | 4762594..4762971 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P8X0 |
| Locus tag | KQ258_RS23180 | Protein ID | WP_001539669.1 |
| Coordinates | 4763061..4763429 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KQ258_RS23145 (4757862) | 4757862..4759400 | - | 1539 | WP_001187189.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
| KQ258_RS25610 (4759660) | 4759660..4759819 | - | 160 | Protein_4551 | integrase | - |
| KQ258_RS23150 (4760283) | 4760283..4760609 | - | 327 | WP_000779482.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KQ258_RS23155 (4760606) | 4760606..4760869 | - | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| KQ258_RS23160 (4760941) | 4760941..4761807 | - | 867 | WP_001290180.1 | DUF4942 domain-containing protein | - |
| KQ258_RS23165 (4761900) | 4761900..4762097 | - | 198 | WP_000839238.1 | DUF957 domain-containing protein | - |
| KQ258_RS23170 (4762109) | 4762109..4762597 | - | 489 | WP_021535504.1 | DUF5983 family protein | - |
| KQ258_RS23175 (4762594) | 4762594..4762971 | - | 378 | WP_000854720.1 | TA system toxin CbtA family protein | Toxin |
| KQ258_RS23180 (4763061) | 4763061..4763429 | - | 369 | WP_001539669.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| KQ258_RS23185 (4763509) | 4763509..4763730 | - | 222 | WP_000692349.1 | DUF987 domain-containing protein | - |
| KQ258_RS23190 (4763817) | 4763817..4764293 | - | 477 | WP_001186788.1 | RadC family protein | - |
| KQ258_RS23195 (4764309) | 4764309..4764794 | - | 486 | WP_000849596.1 | antirestriction protein | - |
| KQ258_RS23200 (4764849) | 4764849..4765667 | - | 819 | WP_001234642.1 | DUF932 domain-containing protein | - |
| KQ258_RS23205 (4765767) | 4765767..4766000 | - | 234 | WP_001119719.1 | DUF905 family protein | - |
| KQ258_RS23210 (4766086) | 4766086..4766490 | + | 405 | WP_001539664.1 | transposase | - |
| KQ258_RS23215 (4766487) | 4766487..4766834 | + | 348 | WP_000612617.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| KQ258_RS23220 (4766883) | 4766883..4768421 | + | 1539 | WP_061186101.1 | IS66-like element ISEc22 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4734459..4764794 | 30335 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14089.02 Da Isoelectric Point: 7.9087
>T206231 WP_000854720.1 NZ_CP076687:c4762971-4762594 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ
Download Length: 378 bp
>T206231 NZ_CP102244:2220489-2220592 [Escherichia coli O7:H15]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 123 a.a. Molecular weight: 13614.39 Da Isoelectric Point: 5.9550
>AT206231 WP_001539669.1 NZ_CP076687:c4763429-4763061 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSN
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSN
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT206231 NZ_CP102244:c2220630-2220362 [Escherichia coli O7:H15]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCTG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCTG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829FW05 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829FYK7 |