Detailed information of TA system TA020623

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-DinJ
• Location: 697662..698187
• Replicon: chromosome
• Accession: NC_002967
• Organism: Treponema denticola ATCC 35405

Toxin (Protein)

• Gene name: relB
• Uniprot ID: Q73PY3
• Locus tag: TDE_RS03195
• Protein ID: WP_002681864.1
• Coordinates: 697662..697925 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73PY2
• Locus tag: TDE_RS03200
• Protein ID: WP_002677040.1
• Coordinates: 697930..698187 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TDE_RS03170	692905..693666	+	762	WP_002681851.1	ABC transporter ATP-binding protein	-
TDE_RS03175	693694..695739	+	2046	WP_002681853.1	FtsX-like permease family protein	-
TDE_RS03180	695780..696292	-	513	WP_002681855.1	ClbS/DfsB family four-helix bundle protein	-
TDE_RS03185	696369..697274	-	906	WP_010956794.1	YafY family transcriptional regulator	-
TDE_RS03190	697336..697575	-	240	WP_002681862.1	hypothetical protein	-
TDE_RS03195	697662..697925	-	264	WP_002681864.1	Txe/YoeB family addiction module toxin	Toxin
TDE_RS03200	697930..698187	-	258	WP_002677040.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
TDE_RS03205	698520..699788	+	1269	WP_002681866.1	OmpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-63)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10463.99 Da
• Isoelectric Point: 9.4465

>T20623 WP_002681864.1 NC_002967:c697925-697662 [Treponema denticola ATCC 35405]
MIKAWDEDAWIDYVYWQTEDKKTLKRINMLIKDIERNGHNGLGSPEPLKGNLSEFWSRRIDKKNRLVYRIADNVIQIIQC
RTHYGEK

Nucleotide

• Length: 264 bp

>T20623 NC_002967:c697925-697662 [Treponema denticola ATCC 35405]
ATGATTAAAGCATGGGATGAAGATGCATGGATAGATTATGTCTATTGGCAAACAGAAGATAAAAAAACACTAAAAAGAAT
CAATATGTTGATTAAAGATATTGAAAGGAATGGTCACAATGGTTTAGGCAGCCCTGAGCCATTAAAGGGAAATCTGTCAG
AATTCTGGAGCCGCAGGATAGATAAAAAAAATAGATTGGTTTATAGAATAGCCGATAATGTAATACAAATAATTCAGTGT
AGAACTCATTATGGTGAAAAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9866.39 Da
• Isoelectric Point: 9.5364

>AT20623 WP_002677040.1 NC_002967:c698187-697930 [Treponema denticola ATCC 35405]
MAQINVNIRMDSEVKQEAEQLFDSLGMNMTTAFNIFIRQSLRIGGIPFKIISDERGFYNKYNQKKLHAAAKRMNEGKYIV
HDIVE

Nucleotide

• Length: 258 bp

>AT20623 NC_002967:c698187-697930 [Treponema denticola ATCC 35405]
ATGGCTCAAATAAATGTCAACATAAGAATGGATTCCGAAGTAAAACAAGAGGCTGAACAGCTTTTTGACAGTTTAGGCAT
GAATATGACAACTGCATTTAATATTTTCATTCGTCAATCATTGAGAATCGGCGGTATACCATTTAAAATTATAAGTGATG
AAAGAGGTTTTTATAATAAATATAATCAAAAAAAACTACATGCTGCTGCTAAACGAATGAATGAAGGGAAATATATAGTG
CATGATATAGTGGAATAG

Structures

Toxin

• AlphaFold DB: Q73PY3

Antitoxin

• AlphaFold DB: Q73PY2