Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3371775..3372609 Replicon chromosome
Accession NZ_CP076687
Organism Escherichia coli strain S22EC

Toxin (Protein)


Gene name yeeV Uniprot ID S1PLF5
Locus tag KQ258_RS16550 Protein ID WP_000854690.1
Coordinates 3372232..3372609 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P7N8
Locus tag KQ258_RS16545 Protein ID WP_001305076.1
Coordinates 3371775..3372143 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ258_RS16505 (3366857) 3366857..3367984 + 1128 Protein_3255 hypothetical protein -
KQ258_RS16510 (3368060) 3368060..3368515 + 456 WP_000581502.1 IrmA family protein -
KQ258_RS16515 (3368594) 3368594..3368827 + 234 WP_000902034.1 DUF905 family protein -
KQ258_RS16520 (3368928) 3368928..3369746 + 819 WP_001234628.1 DUF932 domain-containing protein -
KQ258_RS16525 (3369801) 3369801..3370286 + 486 WP_000849565.1 antirestriction protein -
KQ258_RS16530 (3370302) 3370302..3370778 + 477 WP_001186726.1 RadC family protein -
KQ258_RS16535 (3370841) 3370841..3371062 + 222 WP_000692329.1 DUF987 domain-containing protein -
KQ258_RS16540 (3371081) 3371081..3371725 + 645 WP_000094916.1 hypothetical protein -
KQ258_RS16545 (3371775) 3371775..3372143 + 369 WP_001305076.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KQ258_RS16550 (3372232) 3372232..3372609 + 378 WP_000854690.1 TA system toxin CbtA family protein Toxin
KQ258_RS16555 (3372606) 3372606..3373094 + 489 WP_000761699.1 DUF5983 family protein -
KQ258_RS16560 (3373111) 3373111..3373308 + 198 WP_000839293.1 DUF957 domain-containing protein -
KQ258_RS16565 (3373393) 3373393..3374238 + 846 WP_001529401.1 DUF4942 domain-containing protein -
KQ258_RS16570 (3374307) 3374307..3374702 + 396 WP_000208382.1 DUF6088 family protein -
KQ258_RS16575 (3374695) 3374695..3375628 + 934 Protein_3269 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
KQ258_RS16580 (3376045) 3376045..3376215 + 171 Protein_3270 IS110 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / ugd / kpsT 3330028..3393734 63706
- flank IS/Tn - - 3376060..3376215 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14057.04 Da        Isoelectric Point: 9.1510

>T206225 WP_000854690.1 NZ_CP076687:3372232-3372609 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T206225 NZ_CP102244:c637834-637370 [Escherichia coli O7:H15]
ATGGATTTTCCACAAAGGGTTAATAGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13560.39 Da        Isoelectric Point: 4.7830

>AT206225 WP_001305076.1 NZ_CP076687:3371775-3372143 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT206225 NZ_CP102244:c638169-637834 [Escherichia coli O7:H15]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PLF5


Antitoxin

Source ID Structure
AlphaFold DB S1P7N8

References