Detailed information of TA system TA020622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 558257..558807
• Replicon: chromosome
• Accession: NC_002967
• Organism: Treponema denticola ATCC 35405

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q73QD8
• Locus tag: TDE_RS02450
• Protein ID: WP_002665928.1
• Coordinates: 558257..558538 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QD7
• Locus tag: TDE_RS02455
• Protein ID: WP_002665927.1
• Coordinates: 558535..558807 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TDE_RS02425	553781..554170	-	390	WP_002665934.1	hypothetical protein	-
TDE_RS02430	554275..555402	-	1128	WP_002681624.1	hypothetical protein	-
TDE_RS02435	555584..556648	-	1065	WP_002681626.1	ankyrin repeat domain-containing protein	-
TDE_RS02440	556670..557521	-	852	WP_002681628.1	DUF2262 domain-containing protein	-
TDE_RS02445	557559..558194	-	636	WP_002676860.1	hypothetical protein	-
TDE_RS02450	558257..558538	-	282	WP_002665928.1	type II toxin-antitoxin system YafQ family toxin	Toxin
TDE_RS02455	558535..558807	-	273	WP_002665927.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
TDE_RS02460	558873..559082	-	210	WP_002681636.1	hypothetical protein	-
TDE_RS02465	559133..559849	-	717	WP_002681638.1	hypothetical protein	-
TDE_RS02470	559894..560463	-	570	WP_002681641.1	hypothetical protein	-
TDE_RS02475	560503..561171	-	669	WP_002681642.1	hypothetical protein	-
TDE_RS13140	561374..561532	-	159	WP_010956759.1	hypothetical protein	-
TDE_RS02480	561609..562403	-	795	WP_002681643.1	DUF4261 domain-containing protein	-
TDE_RS02485	562510..562833	-	324	WP_002681645.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11113.98 Da
• Isoelectric Point: 9.8023

>T20622 WP_002665928.1 NC_002967:c558538-558257 [Treponema denticola ATCC 35405]
MKYEIKFTNQFKKDIKLAKKQNKNLDKLLKVIDLLSNGEKLEAKYRDHDLSGNYKGTRECHIEPDWLLVYEIRNDVLVLM
LYRLGSHSELFKK

Nucleotide

• Length: 282 bp

>T20622 NC_002967:c558538-558257 [Treponema denticola ATCC 35405]
ATGAAATACGAAATAAAATTTACAAACCAATTTAAGAAAGATATTAAACTCGCAAAAAAACAGAATAAAAACTTAGATAA
GTTATTGAAAGTTATTGATTTACTTTCAAATGGAGAAAAACTTGAAGCTAAGTATAGAGATCATGATTTATCAGGAAACT
ATAAGGGAACAAGAGAATGTCACATAGAACCGGATTGGCTTTTAGTATATGAAATTAGAAATGATGTACTCGTACTTATG
CTTTATAGACTTGGCTCACATTCAGAGCTTTTTAAAAAATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10205.78 Da
• Isoelectric Point: 5.1486

>AT20622 WP_002665927.1 NC_002967:c558807-558535 [Treponema denticola ATCC 35405]
MATTNLNIRTDKEMKERAEAIFFELGLNMTTAINIFLRTTIRENGIPFALKLDIPNAITASAIEEGRKIAYDDTVKKYSN
IDDLRKALEI

Nucleotide

• Length: 273 bp

>AT20622 NC_002967:c558807-558535 [Treponema denticola ATCC 35405]
ATGGCAACAACAAATTTGAATATCAGAACAGATAAAGAAATGAAGGAGCGAGCAGAAGCTATTTTTTTTGAGTTAGGGCT
TAATATGACAACGGCTATCAATATATTTTTAAGAACAACTATTAGAGAAAATGGAATCCCGTTTGCTTTGAAATTAGATA
TTCCCAATGCAATTACAGCGTCGGCAATAGAAGAAGGTAGAAAAATTGCTTATGATGATACCGTAAAAAAATATTCAAAT
ATAGACGATTTGCGTAAAGCGCTGGAAATATGA

Structures

Toxin

• AlphaFold DB: Q73QD8

Antitoxin

• AlphaFold DB: Q73QD7