Detailed information of TA system TA020621

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 333363..333919
• Replicon: chromosome
• Accession: NC_002967
• Organism: Treponema denticola ATCC 35405

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q73QZ0
• Locus tag: TDE_RS01480
• Protein ID: WP_002676650.1
• Coordinates: 333638..333919 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QZ1
• Locus tag: TDE_RS01475
• Protein ID: WP_002676649.1
• Coordinates: 333363..333641 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TDE_RS01460	330220..330639	+	420	WP_002681243.1	8-oxo-dGTP diphosphatase MutT	-
TDE_RS01465	330983..332413	+	1431	WP_002681245.1	leucyl aminopeptidase	-
TDE_RS01470	332487..333290	+	804	WP_010956712.1	class I SAM-dependent methyltransferase	-
TDE_RS01475	333363..333641	+	279	WP_002676649.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
TDE_RS01480	333638..333919	+	282	WP_002676650.1	type II toxin-antitoxin system YafQ family toxin	Toxin
TDE_RS01485	333996..335552	+	1557	WP_002681251.1	hypothetical protein	-
TDE_RS01490	335735..336841	-	1107	WP_002666350.1	redox-regulated ATPase YchF	-
TDE_RS01495	336880..338709	-	1830	WP_002681253.1	signal peptide peptidase SppA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10774.68 Da
• Isoelectric Point: 10.2467

>T20621 WP_002676650.1 NC_002967:333638-333919 [Treponema denticola ATCC 35405]
MIYQLKKTSQFKASVKLAKKRGLNINLLEGIIEKLRTDTPLGVKHKNHQLSGQFKGIWECHIQPDWLLLYLKEENNLVMT
LVDTGTHSDIFKK

Nucleotide

• Length: 282 bp

>T20621 NC_002967:333638-333919 [Treponema denticola ATCC 35405]
ATGATATATCAATTAAAGAAAACATCTCAGTTTAAAGCAAGTGTCAAATTGGCAAAGAAAAGAGGTTTGAATATTAATCT
TCTTGAAGGTATCATAGAAAAATTAAGGACAGATACGCCGCTTGGGGTAAAACATAAAAATCACCAACTTTCAGGACAGT
TTAAAGGTATTTGGGAGTGTCACATACAACCTGATTGGTTATTATTATATTTAAAAGAAGAAAACAATTTAGTTATGACT
CTTGTTGATACGGGAACACATAGCGATATTTTTAAGAAATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10223.83 Da
• Isoelectric Point: 6.2705

>AT20621 WP_002676649.1 NC_002967:333363-333641 [Treponema denticola ATCC 35405]
MSTAVLQTRVDSQIKKEADDLFNALGIDTTTAIRLFLKQAINQQKIPFEILPPQKEFSPSVLAAIKEARQISCDASVKQY
KTAKELLADCEV

Nucleotide

• Length: 279 bp

>AT20621 NC_002967:333363-333641 [Treponema denticola ATCC 35405]
ATGTCCACTGCAGTATTACAAACGCGAGTTGATAGTCAAATAAAAAAAGAAGCTGATGATCTTTTTAATGCATTAGGTAT
TGATACAACAACTGCAATTCGATTATTTTTAAAGCAAGCTATAAATCAGCAAAAAATTCCTTTTGAAATTCTGCCTCCAC
AAAAAGAATTTTCACCATCTGTTTTAGCCGCGATAAAAGAAGCAAGACAAATCAGTTGTGATGCTTCGGTTAAACAGTAT
AAAACTGCAAAAGAATTGCTTGCGGATTGTGAAGTATGA

Structures

Toxin

• AlphaFold DB: Q73QZ0

Antitoxin

• AlphaFold DB: Q73QZ1