Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4384591..4385225 Replicon chromosome
Accession NZ_CP076679
Organism Rhodopseudomonas palustris strain VNW64

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KQX61_RS20380 Protein ID WP_264053106.1
Coordinates 4384591..4384992 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KQX61_RS20385 Protein ID WP_264053107.1
Coordinates 4384989..4385225 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQX61_RS20345 (KQX61_20250) 4380796..4381137 + 342 WP_264053099.1 type II toxin-antitoxin system RelE/ParE family toxin -
KQX61_RS20350 (KQX61_20255) 4381130..4381453 + 324 WP_114358812.1 transcriptional regulator -
KQX61_RS20355 (KQX61_20260) 4381742..4381981 + 240 WP_264053101.1 hypothetical protein -
KQX61_RS20360 (KQX61_20265) 4382111..4382965 - 855 WP_264053102.1 hypothetical protein -
KQX61_RS20365 (KQX61_20270) 4382996..4383478 - 483 WP_264053103.1 transcription elongation factor GreA -
KQX61_RS20370 (KQX61_20275) 4383539..4384027 - 489 WP_264053104.1 mismatch-specific DNA-glycosylase -
KQX61_RS20375 (KQX61_20280) 4384073..4384474 - 402 WP_264053105.1 DUF2147 domain-containing protein -
KQX61_RS20380 (KQX61_20285) 4384591..4384992 - 402 WP_264053106.1 type II toxin-antitoxin system VapC family toxin Toxin
KQX61_RS20385 (KQX61_20290) 4384989..4385225 - 237 WP_264053107.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KQX61_RS20390 (KQX61_20295) 4385290..4386486 - 1197 WP_264053108.1 TrmJ/YjtD family RNA methyltransferase -
KQX61_RS20395 (KQX61_20300) 4386876..4388099 + 1224 WP_107345565.1 NADP-dependent isocitrate dehydrogenase -
KQX61_RS20400 (KQX61_20305) 4388226..4388558 + 333 WP_264053109.1 YnfA family protein -
KQX61_RS20405 (KQX61_20310) 4388689..4389549 + 861 WP_264053110.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(10-57)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13975.86 Da        Isoelectric Point: 4.4279

>T206201 WP_264053106.1 NZ_CP076679:c4384992-4384591 [Rhodopseudomonas palustris]
VTRYMLDTNILSDLIRNPHGAAVRRIAEVGEGNVCTSIIVAAELRYGCAKSGSVELTKAVADLLEEIDVLPFEPPADEAY
GAIRSSLEAAGTPIGSNDLLIAAHAKSLGATIVTANTQEFGRVQGLAVENWLA

Download         Length: 402 bp

>T206201 NZ_CP102190:c67203-67054 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8911.35 Da        Isoelectric Point: 7.2055

>AT206201 WP_264053107.1 NZ_CP076679:c4385225-4384989 [Rhodopseudomonas palustris]
MTDRRHVRLFRNGRNQAVRIPVEFEMPGNEAIMHREGDRLVIEPVRKRGLIALLQSMTPVDEPFPAIDDPAPAPEKVL

Download         Length: 237 bp

>AT206201 NZ_CP102190:67248-67307 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References