Detailed information of TA system TA206198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 1814761..1815377
• Replicon: chromosome
• Accession: NZ_CP076679
• Organism: Rhodopseudomonas palustris strain VNW64

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: KQX61_RS08435
• Protein ID: WP_264054831.1
• Coordinates: 1815081..1815377 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KQX61_RS08430
• Protein ID: WP_107354811.1
• Coordinates: 1814761..1815078 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQX61_RS08405 (KQX61_08400)	1810013..1810837	-	825	WP_246701592.1	DUF2927 domain-containing protein	-
KQX61_RS08410 (KQX61_08405)	1810906..1811487	-	582	WP_107354806.1	L,D-transpeptidase	-
KQX61_RS08415 (KQX61_08410)	1811668..1813212	+	1545	WP_264054829.1	acetolactate synthase large subunit	-
KQX61_RS08420 (KQX61_08415)	1813326..1813757	+	432	WP_264054830.1	DUF5413 family protein	-
KQX61_RS08425 (KQX61_08420)	1813921..1814241	-	321	WP_107354809.1	hypothetical protein	-
KQX61_RS08430 (KQX61_08425)	1814761..1815078	-	318	WP_107354811.1	putative addiction module antidote protein	Antitoxin
KQX61_RS08435 (KQX61_08430)	1815081..1815377	-	297	WP_264054831.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQX61_RS08445 (KQX61_08440)	1815821..1817101	-	1281	WP_264054832.1	hypothetical protein	-
KQX61_RS08450 (KQX61_08445)	1817342..1817935	-	594	WP_107343619.1	DUF1134 domain-containing protein	-
KQX61_RS08455 (KQX61_08450)	1818043..1818549	+	507	WP_264054833.1	YHS domain-containing (seleno)protein	-
KQX61_RS08460 (KQX61_08455)	1818559..1819494	-	936	WP_264054834.1	2-dehydropantoate 2-reductase N-terminal domain-containing protein	-
KQX61_RS08465 (KQX61_08460)	1819579..1820166	+	588	WP_264054835.1	TetR/AcrR family transcriptional regulator C-terminal ligand-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-94)

Antitoxin

• Uncharacterized protein HI1420 (8-98)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10973.53 Da
• Isoelectric Point: 9.4997

>T206198 WP_264054831.1 NZ_CP076679:c1815377-1815081 [Rhodopseudomonas palustris]
MIDVRETADFTNWLAALSDLRARLQIVRRIDRIAAGNFGDAKSVGGAVKELRIDYGPGYRVYYTRRGDTVVILLCGGDKR
TQSKDIRKAKEIAEALED

Nucleotide

• Length: 297 bp

>T206198 NZ_CP102188:124437-124853 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11410.24 Da
• Isoelectric Point: 10.7447

>AT206198 WP_107354811.1 NZ_CP076679:c1815078-1814761 [Rhodopseudomonas palustris]
MKVSKLKKFNAAEHLRTPEARAEYLNIVLADGDPNEVRDALNLVARAQGMSAIAKAAGVTREGLYKTLGENGNPEFATIL
RVFGAMGFRLTAELAKNKPRRKAVA

Nucleotide

• Length: 318 bp

>AT206198 NZ_CP102188:124210-124440 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA