Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4265426..4266060 Replicon chromosome
Accession NZ_CP076677
Organism Rhodopseudomonas palustris strain PP803

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KQX63_RS19670 Protein ID WP_263989344.1
Coordinates 4265426..4265827 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KQX63_RS19675 Protein ID WP_107345563.1
Coordinates 4265824..4266060 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQX63_RS19630 (KQX63_19550) 4260715..4261065 - 351 WP_263989336.1 helix-turn-helix transcriptional regulator -
KQX63_RS19635 (KQX63_19555) 4261046..4261429 - 384 WP_263991757.1 type II toxin-antitoxin system RelE/ParE family toxin -
KQX63_RS19640 (KQX63_19560) 4261538..4262356 - 819 WP_263989337.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
KQX63_RS19645 (KQX63_19565) 4262814..4263053 + 240 WP_263989338.1 hypothetical protein -
KQX63_RS19650 (KQX63_19570) 4263050..4263775 + 726 WP_263989340.1 Fic family protein -
KQX63_RS19655 (KQX63_19575) 4263825..4264310 - 486 WP_263989341.1 transcription elongation factor GreA -
KQX63_RS19660 (KQX63_19580) 4264371..4264907 - 537 WP_263989342.1 mismatch-specific DNA-glycosylase -
KQX63_RS19665 (KQX63_19585) 4264908..4265309 - 402 WP_263989343.1 DUF2147 domain-containing protein -
KQX63_RS19670 (KQX63_19590) 4265426..4265827 - 402 WP_263989344.1 type II toxin-antitoxin system VapC family toxin Toxin
KQX63_RS19675 (KQX63_19595) 4265824..4266060 - 237 WP_107345563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KQX63_RS19680 (KQX63_19600) 4266125..4267321 - 1197 WP_263989345.1 TrmJ/YjtD family RNA methyltransferase -
KQX63_RS19685 (KQX63_19605) 4267711..4268934 + 1224 WP_107345565.1 NADP-dependent isocitrate dehydrogenase -
KQX63_RS19690 (KQX63_19610) 4269062..4269394 + 333 WP_107345566.1 YnfA family protein -
KQX63_RS19695 (KQX63_19615) 4269525..4270385 + 861 WP_263989346.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4259554..4274487 14933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(10-57)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13908.88 Da        Isoelectric Point: 4.5201

>T206196 WP_263989344.1 NZ_CP076677:c4265827-4265426 [Rhodopseudomonas palustris]
VTRYMLDTSILSDLIRNPHGAAVRCIAEVGEGNVCTSIIVAAELRYGCAKSGSVKLTKAVADLLEEIDVLPFEPPADEVY
GAIRSSLEAAGTPIGSNDLLIAAHAKSLGATIVTANTQEFGRVQGLAVENWVA

Download         Length: 402 bp

>T206196 NZ_CP102187:193445-193915 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8953.47 Da        Isoelectric Point: 8.9339

>AT206196 WP_107345563.1 NZ_CP076677:c4266060-4265824 [Rhodopseudomonas palustris]
MTDRRHVRLFRNGRNQAVRIPVEFEMPGNEAIMHREGDRLVIEPVRKRGLIALLKSMTPLDEPFPVIDDPAPAPEKVL

Download         Length: 237 bp

>AT206196 NZ_CP102187:193005-193448 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References