Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4165425..4166059 Replicon chromosome
Accession NZ_CP076676
Organism Rhodopseudomonas palustris strain TLS06

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KQX62_RS19365 Protein ID WP_264074330.1
Coordinates 4165425..4165826 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KQX62_RS19370 Protein ID WP_164571669.1
Coordinates 4165823..4166059 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQX62_RS19335 (KQX62_19245) 4161611..4162432 - 822 WP_264074325.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
KQX62_RS19340 (KQX62_19250) 4162750..4163133 - 384 WP_264074326.1 hypothetical protein -
KQX62_RS19345 (KQX62_19255) 4163429..4163809 + 381 WP_264074327.1 hypothetical protein -
KQX62_RS19350 (KQX62_19260) 4163828..4164310 - 483 WP_264074328.1 transcription elongation factor GreA -
KQX62_RS19355 (KQX62_19265) 4164371..4164907 - 537 WP_150105176.1 mismatch-specific DNA-glycosylase -
KQX62_RS19360 (KQX62_19270) 4164908..4165309 - 402 WP_264074329.1 DUF2147 domain-containing protein -
KQX62_RS19365 (KQX62_19275) 4165425..4165826 - 402 WP_264074330.1 type II toxin-antitoxin system VapC family toxin Toxin
KQX62_RS19370 (KQX62_19280) 4165823..4166059 - 237 WP_164571669.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KQX62_RS19375 (KQX62_19285) 4166124..4167320 - 1197 WP_264074331.1 TrmJ/YjtD family RNA methyltransferase -
KQX62_RS19380 (KQX62_19290) 4167711..4168934 + 1224 WP_107345565.1 NADP-dependent isocitrate dehydrogenase -
KQX62_RS19385 (KQX62_19295) 4169063..4169395 + 333 WP_107345566.1 YnfA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(10-57)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13975.01 Da        Isoelectric Point: 5.1469

>T206191 WP_264074330.1 NZ_CP076676:c4165826-4165425 [Rhodopseudomonas palustris]
VTRYMLDTSILSDLIRNPHGAAVRRIAEVGEGNVCTSIIVAAELRYGCAKSGSVKLTKAVADLLEEIDVLPFEPPADEVY
GAIRSSLEAAGTPIGSNDLLIAAHAKSLGATIVTANTQKFGRVQGLAVENWLA

Download         Length: 402 bp

>T206191 NZ_CP102186:c4874997-4874713 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8939.44 Da        Isoelectric Point: 8.9339

>AT206191 WP_164571669.1 NZ_CP076676:c4166059-4165823 [Rhodopseudomonas palustris]
MTDRRHVRLFRNGRNQAVRIPVEFEMPGNEAIMHREGDRLVIEPVRKRGLIALLKSMTPVDEPFPVIDDPAPAPEKVL

Download         Length: 237 bp

>AT206191 NZ_CP102186:c4875229-4874987 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References